background: sodium arsenite (naaso2) has potent cytotoxic activity in human cancer cells. oxidative stress has been suggested as a mechanism for arsenic-induced carcinogenesis. the purpose of the present study was to evaluate the alteration of mrna levels of catalase ( cat ) and superoxide dismutase 2 ( sod2 ) in mcf-7 and jurkat cells after exposure to naaso 2 . methods: methylthiazol tetrazol...

conclusions these outcomes support our theory that rapamycin increases oxidative stress in mcf-7 and mda mb-231 cells but also shows high levels of antioxidant effects, which probably limit the effects of the rapamycin on the same issue in the clinic. methods the mcf-7 and mda mb-231 cell lines were cultivated and treated with rapamycin for 72 hours. the viability of the cells was determined us...

background: nigella sativa has been a nutritional flavoring factor and natural treatment for many ailments for so many years in medical science. earlier studies have been reported that thymoquinone (tq), an active compound of its seed, contains anticancer properties. previous studies have shown that tq induces apoptosis in breast cancer cells but it is unclear the role of p53 in the apoptotic p...

background: disulfiram is oral aldehyde dehydrogenase (aldh) inhibitor that has been used in the treatment of alcoholism. recent studies show that this drug has anticancer properties; however, its rapid degradation has limited its clinical application. encapsulation of disulfiram polymeric nanoparticles (nps) may improve its anticancer activities and protect rapid degradation of the drug. mater...

conclusions this study suggests that the il-7 level of chb patients may be related to tfh cells. in chb patients, il-7 possibly increases the level of tfh cells and hbv-specific cellular immune responses and thereby reduces the hbv dna level. background in patients with chronic hepatitis b (chb), the relation of interkeukin-7 (il-7) to either the t follicular helper cells (tfh cells) or to a sp...

background: many in vitro studies suggested that choline incorporation into many types of tumors is related to cell proliferation. whether in vivo choline incorporation is related also to cell proliferation or not was my question. therefore, the aim of this pilot study was to investigate the relationship of in vivo [methyl- 14c]-choline incorporation and in vivo [methyl-3h]- thymidine incorpora...

mycophenolic acid (mpa) is the active metabolite of mycophenolate mofetil. this study designed to investigate the mechanism of cytotoxicity of mpa on the genetically engineered pc12 tet off (pto) neuronal cells with p53 gene. alamar blue (ab) reduction showed concentration-dependent cytotoxicity of mpa on pto cells with ic50 value of 32.32 ± 4.61 mm. the reactive oxygen species (ros) generation...

objective: bone morphogenetic protein-7 (bmp-7) is a multifunctional growth factor predominantly recognized for its osteoinductive properties. due to the high cost of this protein, the availability of bmp-7 for treatment is limited. the heterologous production of recombinant hbmp-7 has been performed in a number of expression systems. in this study a novel form of bmp-7 was expressed in eukaryo...