نتایج جستجو برای: 68ga dotatate petct

تعداد نتایج: 2155  

Journal: :European Journal of Hybrid Imaging 2021

Abstract Background Pancreatic neuroendocrine tumor (PNET) is a subgroup of (NET) that has unique biology and natural history. The histological classification major role in the management this pathology, but recent years Gallium 68 dotatate (68Ga-DOTA) scanning at center discussion about how these imaging technologies can modify clinical tumors their results are correlated to Ki67 index. Method...

Journal: :Acta radiologica 2014
Jigang Yang Ying Kan Benjamin H Ge Leilei Yuan Chunlin Li Wenrui Zhao

BACKGROUND Gallium-68 somatostatin receptor positron emission tomography (PET) has been used in the diagnosis of neuroendocrine tumors (NETs). The compounds often used in molecular imaging of NETs with PET are 68Ga-DOTATOC, 68Ga-DOTATATE, and 68Ga-DOTANOC. There is varying affinity to different somatostatin receptors. PURPOSE To systematically review and perform a meta-analysis of published d...

2012
Xiang Li Samuel Samnick Constantin Lapa Ina Israel Andreas K Buck Michael C Kreissl Wolfgang Bauer

BACKGROUND Ga-[1,4,7,10-tetraazacyclododecane-N,N',N″,N'″-tetraacetic acid]-d-Phe1,Tyr3-octreotate (DOTATATE) positron emission tomography (PET) is commonly used for the visualization of somatostatin receptor (SSTR)-positive neuroendocrine tumors. SSTR is also known to be expressed on macrophages, which play a major role in inflammatory processes in the walls of coronary arteries and large vess...

2017
Ronald Walker Stephen Deppen Gary Smith Chanjuan Shi Jonathan Lehman Jeff Clanton Brandon Moore Rena Burns Eric L. Grogan Pierre P. Massion

PURPOSE 18F-FDG PET/CT is widely used to evaluate indeterminate pulmonary nodules (IPNs). False positive results occur, especially from active granulomatous nodules. A PET-based imaging agent with superior specificity to 18F-FDG for IPNs, is badly needed, especially in areas of endemic granulomatous nodules. Somatostatin receptors (SSTR) are expressed in many malignant cells including small cel...

2017
Jason M. Tarkin Francis R. Joshi Nicholas R. Evans Mohammed M. Chowdhury Nichola L. Figg Aarti V. Shah Lakshi T. Starks Abel Martin-Garrido Roido Manavaki Emma Yu Rhoda E. Kuc Luigi Grassi Roman Kreuzhuber Myrto A. Kostadima Mattia Frontini Peter J. Kirkpatrick Patrick A. Coughlin Deepa Gopalan Tim D. Fryer John R. Buscombe Ashley M. Groves Willem H. Ouwehand Martin R. Bennett Elizabeth A. Warburton Anthony P. Davenport James H.F. Rudd

BACKGROUND Inflammation drives atherosclerotic plaque rupture. Although inflammation can be measured using fluorine-18-labeled fluorodeoxyglucose positron emission tomography ([18F]FDG PET), [18F]FDG lacks cell specificity, and coronary imaging is unreliable because of myocardial spillover. OBJECTIVES This study tested the efficacy of gallium-68-labeled DOTATATE (68Ga-DOTATATE), a somatostati...

Objective(s): In view of somatostatin receptor (SSR) expression on cell membranes of the majority of neuroendocrine tumors (NETs), functional imaging exploiting analogs of SSR alongside the anatomical imaging is the mainstay of this diagnostic modality. In this prospective study, we assessed and directly compared the diagnostic parameters of 68Ga-DOTATATE PET/CT and 99...

2017
Iulia Dude Zhengxing Zhang Julie Rousseau Navjit Hundal-Jabal Nadine Colpo Helen Merkens Kuo-Shyan Lin François Bénard

Background The somatostatin receptor subtype 2 (sstr2) is expressed on a majority of luminal breast cancers, however SPECT and scintigraphy imaging with agonistic sstr2 probes has been sub-optimal. High affinity antagonists can access more binding sites on the cell surface, resulting in higher tumor uptake and improved sensitivity. We compared the tumor uptake and biodistribution of the antagon...

Journal: :iranian journal of nuclear medicine 2016
ayuob aghanejad amir reza jalilian stephan maus hassan yousefnia parham geramifar

introduction: optimized production and quality control of 68ga-dotatate as an efficient and preferable pet radiotracer for somatostatin receptor imaging in neuroendocrine tumors is of great interest. in this study effort has been made to present a fast, efficient, cost-effective and facile protocol for 68ga-dotatate productions for clinical trials. methods:68ga-dotatatewas prepared using genera...

Journal: :Revista espanola de medicina nuclear e imagen molecular 2015
E Demirci R Akyel F Kilic F Kantarci M Halac K Sonmezoglu

68Ga-labeled octreotide analogs, including DOTATOC, DOTATATE and DOTANOC, are very useful PET radiopharmaceuticals in the management of neuroendocrine tumors (NETs). However, a considerable number of malignancies beyond NETs, including lymphomas, express somatostatin receptors and are eligible to accumulate radiolabeled octreotide analogs, leading to misleading findings on somatostatin receptor...

2016
Duygu Has Şimşek Serkan Kuyumcu Bilge Bilgiç Emine Göknur Işık Cüneyt Türkmen Işık Adalet

A 54-year-old woman with suspicion of neuroendocrine tumor (NET) was referred for 68Ga-DOTATATE positron emission tomography/computed tomography (CT) imaging due to clinical findings. A well-defined osteolytic lesion on the corpus of the third lumbar vertebra was evident on CT images with mild uptake of 68Ga-DOTATATE, which led to suspicion of NET metastasis. Histopathologic examination reveale...

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