نتایج جستجو برای: 629

تعداد نتایج: 1704  

2009
Shensi Shen Pengtao Zhang Martin A. Lovchik

The molecular chaperone Hsp90 (heat shock protein 90) maintains the conformation, stability, and activity of several key oncogenic proteins, such as EGF receptor (EGFR), cyclin-dependent kinases, Raf, and p53, which are collectively known as Hsp90 client proteins (Whitesell and Lindquist, 2005). The chaperone function of Hsp90 requires the formation of a multichaperone complex, which is depende...

2005
William Davies Anthony Isles Rachel Smith Delicia Karunadasa Doreen Burrmann Trevor Humby Obah Ojarikre Carol Biggin David Skuse Paul Burgoyne Lawrence Wilkinson

Imprinted genes show differential expression between maternal and paternal alleles as a consequence of epigenetic modification that can result in ‘parent-of-origin’ effects on phenotypic traits1. There is increasing evidence from mouse and human studies that imprinted genes may influence behavior and cognitive functioning2. Previous work in girls with Turner syndrome (45,XO) has suggested that ...

2013
Dorothee Kümmerer Gesa Hartwigsen Philipp Kellmeyer Volkmar Glauche Irina Mader Stefan Klöppel Julia Suchan Hans-Otto Karnath Cornelius Weiller Dorothee Saur

1 Department of Neurology, University Medical Centre Freiburg, 79106 Freiburg, Germany 2 Freiburg Brain Imaging, University Medical Centre Freiburg, 79106 Freiburg, Germany 3 Language and Aphasia Laboratory, Department of Neurology, University of Leipzig, 04103 Leipzig, Germany 4 Department of Neuroradiology, University Medical Centre Freiburg, 79106 Freiburg, Germany 5 Department of Psychiatry...

2002
Ira N. Gang Kunal Sen Myeong-Su Yun IZA Bonn

Caste, Ethnicity and Poverty in Rural India This paper analyzes the determinants of rural poverty in India, contrasting the situation of the Scheduled Caste (SC) and Schedule Tribe (ST) households with the non-scheduled population. The incidence of poverty among SC and ST households is significantly higher than non-scheduled households. Using a probit decomposition analysis, we decompose the di...

2017
Neoh Hun Phuah Mohamad Nurul Azmi Khalijah Awang Noor Hasima Nagoor

BACKGROUND Cervical cancer is the fourth most frequent malignancy affecting women worldwide, but drug resistance and toxicities remain a major challenge in chemotherapy. The use of natural compounds is promising because they are less toxic and able to target multiple signaling pathways. The 1'S-1'-acetoxychavicol acetate (ACA), a natural compound isolated from wild ginger Alpinia conchigera, in...

2015
Pavan Prabhala Alaina J. Ammit

Chronic inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are clinically and socioeconomically important diseases globally. Currently the mainstay of anti-inflammatory therapy in respiratory diseases is corticosteroids. Although corticosteroids have proven clinical efficacy in asthma, many asthmatic inflammatory conditions (e.g., infection, exacerbation, an...

Journal: :Endocrinology 2007
Moulun Luo Paul Langlais Zhengping Yi Natalie Lefort Elena A De Filippis Hyonson Hwang Christine Y Christ-Roberts Lawrence J Mandarino

The function of insulin receptor substrate-1 (IRS-1) is regulated by both tyrosine and serine/threonine phosphorylation. Phosphorylation of some serine/threonine residues in IRS-1 dampens insulin signaling, whereas phosphorylation of other serine/threonine residues enhances insulin signaling. Phosphorylation of human IRS-1 at Ser(629) was increased by insulin in Chinese hamster ovary cells expr...

Journal: :Molecular cancer research : MCR 2015
Kentaro Jingushi Yuko Ueda Kaori Kitae Hiroaki Hase Hiroshi Egawa Ikumi Ohshio Ryoji Kawakami Yuri Kashiwagi Yohei Tsukada Takumi Kobayashi Wataru Nakata Kazutoshi Fujita Motohide Uemura Norio Nonomura Kazutake Tsujikawa

UNLABELLED Renal cell carcinoma (RCC) is the most common neoplasm of the adult kidney, and clear cell RCC (ccRCC) represents its most common histological subtype. To identify a therapeutic target for ccRCC, miRNA expression signatures from ccRCC clinical specimens were analyzed. miRNA microarray and real-time PCR analyses revealed that miR-629 expression was significantly upregulated in human c...

2015
Sylvia Grierson Judith Heaney Tanya Cheney Dilys Morgan Stephen Wyllie Laura Powell Donald Smith Samreen Ijaz Falko Steinbach Bhudipa Choudhury Richard S. Tedder

Since 2010, reports of infection with hepatitis E virus (HEV) have increased in England and Wales. Despite mounting evidence regarding the zoonotic potential of porcine HEV, there are limited data on its prevalence in pigs in the United Kingdom. We investigated antibody prevalence, active infection, and virus variation in serum and cecal content samples from 629 pigs at slaughter. Prevalence of...

Journal: :Keria: Studia Latina et Graeca 2010

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