miRNAs play critical role in the development and progression of prostate cancer. Here we studied the role of miR-618 in prostate cancer migration and invasion. miR-618 was downregulated in metastatic androgen-independent prostate cancer (AIPC), patients with low miR-618 had poor outcome. Overexpression of miR-618 inhibited migration and invasion and induced mesenchymal to epithelial transition ...

Protein motions are important to activity, but quantitative relationships between internal dynamics and function are not well understood. The Dbl homology (DH) domain of the proto-oncoprotein and guanine nucleotide exchange factor Vav1 is autoinhibited through interactions between its catalytic surface and a helix from an N-terminal acidic region. Phosphorylation of the helix relieves autoinhib...

MSNE assumes players use a random device privately and independently, that tells them which strategy to choose for any given play. The Bayesian environment, we have discussed so far assumes that signals are random, private and independent. The question that we address here is what happens if the signals are random but public (not private) and not independent across the agents and further, the a...

The antimicrobial activity of different extracts of Piper regnellii was evaluated through the broth microdilution assay. The leaves, roots and stems extracts presented a good activity against Staphylococcus aureus and Bacillus subtilis with minimal inhibitory concentration (MIC) between 31.25 62.5 μg/ml. Although the differences were not significant, the leaves hydroalcoholic extract tended to ...

We investigated the transforming activity of the ret proto-oncogene with a mutation in cysteine 609, 611, 618, 620, 630, or 634 detected in patients with multiple endocrine neoplasia type 2A (MEN 2A), familial medullary thyroid carcinoma (FMTC), or Hirschsprung's disease. Of these cysteine mutations, codon 634 mutations are known to be correlated with the development of MEN 2A, whereas codon 60...

INTRODUCTION .............................................................. 609 MATERIALS AND METHODS ...................... ........................... 609 Media..................................................................... 609 Strains .................................................................... 609 S. typhimurium ............................................................. 609...