131I-TM-601 is a 36-amino acid peptide, called chlorotoxin (TM-601), derived from scorpion venom labeled with I-131. TM-601 binds a receptor on the surface of tumor cells, and not on normal cells. A single dose of 131I-TM-601 administered intracranially to human xenografted mouse models of glioma has been shown to extend survival up to 269% in multiple studies. 131I-TM-601 is in a multi-center ...

131I-TM-601 is a 36-amino acid peptide, called chlorotoxin (TM-601), derived from scorpion venom labeled with I-131. TM-601 binds a receptor on the surface of tumor cells, and not on normal cells. A single dose of 131I-TM-601 administered intracranially to human xenografted mouse models of glioma has been shown to extend survival up to 269% in multiple studies. 131I-TM-601 is in a multi-center ...

GENERIC NAME PAGE Amphotericin B 596 Butoconazole 601 Capsofungin 601 Ciclopirox 602 Clotrimazole 600 Econazole 601 Fluconazole 598 Flucytosine 601 Griseofulvin 602 Itraconazole 599 Ketoconazole 599 GENERIC NAME PAGE Miconazole 600 Naftifine hydrochloride 602 Nystatin 598 Oxiconazole nitrate 601 Sulconazole nitrate 601 Terbinifine hydrochloride 602 Terconazole 601 Tioconazole 601 Tolnaftate 602...

The present study was performed to characterize the disposition and alpha(1)-adrenoceptor binding of JTH-601, a novel alpha(1L)-adrenoceptor antagonist, and its metabolites (beta-D-glucopyranosyl uronic acid, JTH-601-G1; hydrogen sulfate, JTH-601-S1) in the rat prostate and other tissues. JTH-601, JTH-601-G1, and JTH-601-S1 inhibited competitively specific [(3)H]tamsulosin binding in the prosta...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 185 No. 4 601–612 www.jcb.org/cgi/doi/10.1083/jcb.200901145 JCB 601 R.W. Klemm and C.S. Ejsing contributed equally to this paper. Correspondence to Kai Simons: [email protected] Abbreviations used in this paper: COPI, coat protein I; GP, general polarization; GPI, glycosyl-PI; HDSV, heavy density secretory vesicle; InvRFP, invertase-RFP...

Please answer to the point, and do not spend time/space giving irrelevant details. Please state any additional assumptions you make while answering the questions. For Questions 1 to 5, 6(b) and 6(c), you need to submit your answers in a single PDF file on autolab, either a scanned handwritten version or a LTEXpdf file. Please make sure you write legibly for grading. For Question 6(a), submit yo...

activity-based costing Costing method that breaks down the organization into a set of activities, and activities into tasks, which convert materials, labour and technology into outputs. activity time The time required to perform one activity at one station. adequate service The level of service quality a customer is willing to accept. adverse conditions Positive and negative employee actions un...

Organic anion–transporting polypeptide 1B1 (OATP1B1) is an important hepatic uptake transporter, of which the polymorphic variant OATP1B1*15 (Asn130Asp and Val174Ala) has been associated with decreased transport activity. Rosuvastatin is an OATP1B1 substrate and often concomitantly prescribed with oral antidiabetics in the clinic. The aim of this study was to investigate possible drug-drug inte...

The present study was performed to characterize the disposition and a1-adrenoceptor binding of JTH-601, a novel a1L-adrenoceptor antagonist, and its metabolites (b-D-glucopyranosyl uronic acid, JTH-601-G1; hydrogen sulfate, JTH-601-S1) in the rat prostate and other tissues. JTH-601, JTH-601-G1, and JTH-601-S1 inhibited competitively specific [H]tamsulosin binding in the prostate, submaxillary g...