Parkinson's disease (PD) is characterized by a myriad of symptoms, encompassing both motor disabilities and cognitive impairments. Recent research has shown that abscisic acid (ABA) phytohormone found in various brain regions several mammals exhibits neuroprotective properties. To investigate the effects ABA on disorders, mouse model PD was utilized. The administration 6-hydroxydopamine (6-OHDA...

Abstract: Aim/Background: Parkinson’s Disease (PD), the loss of dopaminergic neurons in substantial nigra part brain leading to neurodegeneration. Materials and Methods: The objective this study was observe neuroprotective effect synthesized derivatives 6-hydroxydopamine (6-OHDA) induced rat model. Here, designed naphthalene substituted azetidinone compounds defended lesions caused by 6-OHDA mo...

Parkinson’s disease (PD) is neurodegenerative disease, which accompanied by degeneration of dopaminergic neurons in subtantia nigra. Non-motor symptoms, particular, disorders the gastrointestinal (GI) tract are observed 20-80% patients some 15-20 years before clinically diagnosed PD and not a least important feature pathogenesis. The transient receptor potential (TRP) channels expressed through...

This study aimed to evaluate the effects of two different protocols for physical exercise (strength and aerobic training) on mitochondrial and inflammatory parameters in the 6-OHDA experimental model of Parkinson's disease. Six experimental groups were used (n = 12 per group): untrained + vehicle (Sham), strength training + vehicle (STR), treadmill training + vehicle (TTR), untrained + 6-OHDA (...

BACKGROUND Damage of the medial prefrontal cortex (mPFC) results in similar characteristics to the cognitive deficiency seen with the progress of Parkinson's disease (PD). Since the course of mPFC damage is still unclear, our study aimed to investigate the effects of melatonin (MT) on neurotoxicity in the mPFC of a rat model of PD. METHODS One hundred and fifty-four normal, male Wistar rats w...

We studied and compared the effects of 5- and 6-hydroxydopamine (5- or 6-OHDA) on venous tone and on adrenergic and nonadrenergic responses of the isolated canine saphenous vein. In the tissue bath, both 5- and 6-OHDA caused increases in tone and abolished adrenergic responses to transmural nerve stimulation. Effects of 6-OHDA were blocked by desmethylimipramine. 6-OHDA reduced norepinephrine l...

Abstract Parkinson’s disease (PD) is the second-most common neurodegenerative worldwide. Several studies have investigated PD for decades; however, exact mechanism of development remains unknown. To study PD, SH-SY5Y cells are often treated with 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenylpyridinium (MPP+) to induce PD. understand pathogenesis, we confirmed protein changes between 6-OHDA- an...

BackgroundCurcumin is a natural compound with extensive pharmacological effects. This research to verify the optimal dose and administration duration efficacy of curcumin in alleviating movement symptoms Parkinson's disease (PD).MethodsWistar rats were divided into six groups including control, model, levodopa treatment low/middle/high (40/80/160 mg/kg/d) groups. After stereotactic brain inject...

The neurotoxin 6-hydroxydopamine (6-OHDA) has been widely used to generate an experimental model of Parkinson's disease. It has been reported that reactive oxygen species (ROS), such as the superoxide anion and hydrogen peroxide (H2O2), generated from 6-OHDA are involved in its cytotoxicity; however, the contribution and role of ROS in 6-OHDA-induced cell death have not been fully elucidated. I...

The objective of the present study was to determine whether lesion of the subthalamic nucleus (STN) promoted by N-methyl-D-aspartate (NMDA) would rescue nigrostriatal dopaminergic neurons after unilateral 6-hydroxydopamine (6-OHDA) injection into the medial forebrain bundle (MFB). Initially, 16 mg 6-OHDA (6-OHDA group) or vehicle (artificial cerebrospinal fluid - aCSF; Sham group) was infused i...