نتایج جستجو برای: 6 hydroxy dopamine
تعداد نتایج: 1020826 فیلتر نتایج به سال:
Bacoside-A, a major constituent isolated from Bacopa monniera is held in high repute as a potent nerve tonic. Rats were pretreated with Bacoside A (10mg/kg and 20mg/kg body weight) for 21 days. A Parkinsonian model in rats was developed by giving 6-hydroxy dopamine (12μg/2μl in 0.1% ascorbic acidsaline) in the right striatum on 22 day. A significant protection on lipid peroxidation, glutathione...
در این کار پژوهش بیشتر سنتز ترکیبهای مختلف سه حلقه ای فنل با یک نوع هالوژن و هالوژنهای مختلف و کندن برم از آنها موردنظر است و مشتقهای مختلف از این نوع ترکیبات که در زیر شرح داده شده است سنتز گردیده است . علاوه براین از روشهای سنتزی برای تائید ساختمان ترکیبهای سه حلقه ای استفاده شده است . همچنین سنتز این ترکیبها امکان میدهد که خواص بیولوژیکی و شیمیائی آنها با ترکیبات مشابه دوحلقه ای و چهارحلقه ا...
Background & Objective: The axial role of the oxidative stress in the pathophysiology of Parkinson disease has been identified. On the other hand, the learning and memory impairment in Parkinson disease has a distinguished outlook. Since Saffron has antioxidative stress effects, the aim of the present study is to investigate the improving effects of Saffron extract on the spatial memory paramet...
Excitatory amino acid (EAA) receptor-mediated events have recently been implicated in dopaminergic mechanisms of neurotoxicity. 2,4,5-Trihydroxyphenylalanine (6-hydroxy-DOPA, TOPA), the ortho-hydroxylated derivative of the dopamine precursor 2,4-dihydroxyphenylalanine (L-DOPA), has recently been reported to have neurotoxic properties which are blocked by CNQX, a specific antagonist of the AMPA ...
Objective(s): The present study was conducted to examine the effect of sleep deprivation (SD) on the anti-apoptotic pathways in Parkinsonian rats. Materials and Methods: Male Wistar rats (n = 40) were assigned to four groups (10 animals each): sham surgery (Sham), 6-hydroxydopamine (6-OHDA)-lesioned (OH), 6-OHDA-lesioned plus grid control (OH+GC), 6-OHDA-lesioned plus SD (OH+SD). Parkinson’s di...
Objective: Menthaaquatica, plant which is showing monoamine oxidase-B (MAO-B) inhibition and antioxidant activity was assessed for anti-Parkinson’s activity in 6-hydroxy dopamine (6-OHDA) lesionedwistar rat model. Materials and Method: Menthaaquaticaethanolextract (EMA) was obtained by using alcoholic solvent. Acute oral toxicity of Menthaaquaticaextract was carried out in wistar rats. Rats wer...
Background: We investigated the effects of 12 weeks of voluntary exercise on a running wheel with extraction of flowers Eriobotrya japonica on GDNF in the brain stem induced by 6-hydroxy dopamine. Methods: In this study, 43 rats were divided into six groups: healthy control, parkinsonian control, training group, parkinsonian training, extract parkinson, training-extract parkinsonian. Tra...
In the present study, R-(-)-apomorphine and three of its analogs were studied for their potency in decreasing the release of dopamine in the striatum after subcutaneous administration and for their oral bioavailability using the microdialysis technique in freely moving rats. The analogs R-(-)-N-n-propylnorapomorphine and R-(-)-11-hydroxy-N-n-propylnoraporphine displayed a higher potency than R-...
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