نتایج جستجو برای: 6 diaminopyrimidines

تعداد نتایج: 956340  

2011
Luke Mercer Tana Bowling Joe Perales Jennifer Freeman Tien Nguyen Cyrus Bacchi Nigel Yarlett Robert Don Robert Jacobs Bakela Nare

BACKGROUND There is an urgent need to develop new, safe and effective treatments for human African trypanosomiasis (HAT) because current drugs have extremely poor safety profiles and are difficult to administer. Here we report the discovery of 2,4-diaminopyrimidines, exemplified by 4-[4-amino-5-(2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid phenylamide (SCYX-5070), as pot...

Journal: :Letters in Drug Design & Discovery 2008

Journal: :Public Health Reports (1896-1970) 1952

Journal: :British Journal of Pharmacology and Chemotherapy 1951

2002
GERTRUDE B. ELION GEORGE H. HITCHINGS

Inhibition of the growth of Lactobadlus casei with folic acid as the nutrilite is a general property of 2,4-diaminopyrimidines, 2-aminopyrimidines, and condensed systems containing these groupings (1). These compounds comprise a spectrum of inhibitors. At one end lie the simpler diaminopyrimidines which are competitive antagonists of folic acid (1, 2). The center may be represented by 2-aminopu...

2017
Michael Wegener Mickel J Hansen Arnold J M Driessen Wiktor Szymanski Ben L Feringa

The field of photopharmacology aims to introduce smart drugs that, through the incorporation of molecular photoswitches, allow for the remote spatial and temporal control of bioactivity by light. This concept could be particularly beneficial in the treatment of bacterial infections, by reducing the systemic and environmental side effects of antibiotics. A major concern in the realization of suc...

2015
Marjan Esfahanizadeh Shohreh Mohebbi Behnam Dasht Bozorg Salimeh Amidi Ali Gudarzi Seyed Abdolmajid Ayatollahi Farzad Kobarfard

A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tested derivatives, compounds Ia, Ib, IB and II16 exhibited the highest antiplatelet aggregation act...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید