BACKGROUND It is a well-known fact that 5HT6 ligands increase glutamate levels. In the current study we investigated whether a 5HT6 antagonist, SB399885 would show antidepressant like property at a dose which would significantly increase the glutamate levels. Further we studied if the combination of a 5HT6 antagonist and N-methyl-D-aspartate (NMDA) antagonist, memantine would restore the antide...

Cognitive impairment is the major health problem in normal aged life as well as in some disease conditions. Cognition enhancers can be used to facilitate attention abilities and acquisition, storage and retrieval of information, and to attenuate the impairment of cognitive functions associated with age and age-related pathologies. In course of time, numbers of neurotransmitters and signaling mo...

BACKGROUND The World Health Organization (WHO) report has predicted that major depression will become a key cause of illness-induced disability by the year 2020, second only to ischemic heart diseases. OBJECTIVES/METHODS Although a large number of antidepressant drugs (from monoamine oxidase inhibitors and tricyclic antidepressants to dual reuptake inhibitors) are available for treatment of t...