background: this study testing the effectiveness ,toxicity and tolereability of new chemotherapeutic regimen (consist of irinotecan 5-fu and leucovorin) in locally advanced and metastatic gastric cancer. patients and methods: patients with locally advanced gstric cancer (atleast stage 3)or metastatic gastric cancer that no treated previously with chemotherapeutic agents entered onto this study....

Calcification within the lesion of liver metastases is a well-known phenomenon. It occurs in 12-27% of hepatic colorectal metastases, but its clinical significance and its influence on prognosis are controversial. The calcification is either produced by the tumor itself or represents dystrophic calcification secondary to necrosis and/or haemorrhage within the tumor before or during chemotherapy...

Standard treatment for advanced pancreatic cancer has had minimal impact on natural course of the disease. Current standard chemotherapy for healthy, robust patients remains FOLFIRINOX (5fluorouracil, leucovorin, oxaliplatin, and irinotecan) chemotherapy which showed 4-month overall survival benefit compared to gemcitabine alone [2]. Recently MPACT study showed that adding nabpaclitaxel to gemc...

The resistance of a Novikoff hepatoma cell line (Ni -Si I FdUrd) to 5-fluorouracil (FUra) was reversed by the inclusion of inosine in the culture medium. As the concentration of inosine in the medium was increased, there was a marked increasein the uptakeof [14C]FUra nd conversionto nucleo tides with a corresponding increase in the incorporation into RNA. While FUra alone had no effect on this ...

In cell cultures of Detroit 6, KB, and HeLa cells, treatment with certain amounts of 5Fluorouracil resulted in the appearance of a strikingly distinct halo or chromophobic area, entirely encircling the compacted or contracted nucleoli, before the ultimate disintegration of the cells. ∗PMID: 4221925 [PubMed indexed for MEDLINE] Copyright c ©OKAYAMA UNIVERSITY MEDICAL SCHOOL Acta Med. Okayama 19,...

–Pterygium is a fibrovascular proliferation of conjunctiva onto the cornea which leads to considerable visual impairment due to corneal astigmatism. Surgical excision is the only treatment; however recurrence continues to be a complication. Therefore, ant metabolites like Mitomycin C & 5Fluorouracil have been used as chemoadjuvant to reduce it. Present study was carried out to evaluate the effi...

PURPOSE To evaluate the treatment outcomes of patients with locally advanced rectal cancer treated with preoperative concurrent chemoradiotherapy (CCRT) or combined chemotherapy together with radiotherapy (CMTRT) without surgery. MATERIALS AND METHODS A total of 84 patients with locally advanced rectal adenocarcinoma (stage II or III) between January 1st, 2003 and December 31st, 2013 were enr...

Takeshi Nagasaka, Hideyuki Mishima, Akira Sawaki, Mototsugu Shimokawa, Michio Inukai, Katsunori Shinozaki, Hiroaki Tanioka, Junichiro Nasu, Tomohiro Nishina, Shoichi Hazama, Masazumi Okajima, Yoshiyuki Yamaguchi To cite: Nagasaka T, Mishima H, Sawaki A, et al. Protocol of a randomised phase III clinical trial of sequential capecitabine or 5fluorouracil plus bevacizumab (Cape/5-FU-Bmab) to capec...

The non-proliferative activity of isolated saponins, gymnemagenol (C30H50O4) from Gymnema sylvestre and dasyscyphin C (C28H40O8) from Eclipta prostrata leaves were tested under on HepG2 cells under in vitro conditions. Both gymnemagenol and dasyscyphin C exhibited non-proliferative activity on HepG2 cells at 24 h with the IC50 value of 18.5 and 23.5μg/ml respectively. 5Fluorouracil (5FU) a posi...

EPDS: erosive pustular dermatosis of the scalp INTRODUCTION Erosive pustular dermatosis of the scalp (EPDS) is an uncommon condition that is reported after local injuries including burns, cryotherapy, radiation therapy, photodynamic therapy, skin grafts, and hair transplantation as well as topical medication treatments including retinoids, imiquimod, and 5fluorouracil. We present a case of eros...