Guillaume Lettre1,2, Anne U Jackson3,25, Christian Gieger4,5,25, Fredrick R Schumacher6,7,25, Sonja I Berndt8,25, Serena Sanna3,9,25, Susana Eyheramendy4,5, Benjamin F Voight1,10, Johannah L Butler2, Candace Guiducci1, Thomas Illig4, Rachel Hackett1, Iris M Heid4,5, Kevin B Jacobs11, Valeriya Lyssenko12, Manuela Uda9, The Diabetes Genetics Initiative24, FUSION24, KORA24, The Prostate, Lung Colo...

* Department of Biology, University of California at San Diego, La Jolla, California 92093-0357, USA § Mikoshiba Calciosignal Net Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Corporation (JST), Tokyo 113-0021, Japan 2 These authors contributed equally to this work. 3 Present address: Department of Biochemistry, New York University School of Medicin...

TWIST1, a transcription factor, plays a pivotal role in cancer initiation and progression. Anaplastic thyroid carcinoma (ATC) is one of the deadliest human malignancies; TWIST1 is overexpressed in ATC and increases thyroid cancer cell survival, migration and invasion. The molecular mechanisms underlying the effects of TWIST1 are partially known. Here, using miRNome profiling of papillary thyroi...

Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 584 Step 1: developing the study question . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 584 Defining the study question . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

BACKGROUND Uncovering the target gene of miR-584 to control thyroid carcinoma (TC) invasion and migration is of central importance in the diagnosis, treatment, and prognosis of TC. To validate whether miR-584 has a tumor-suppressive role in thyroid cancer cells by targeting ROCK1, a series of experiments were conducted to figure out the mechanism of action of miR-584. MATERIAL AND METHODS Mig...

When Laveran (1) discovered living malarial parasites over 65 years ago in the blood of patients with certain fevers, a new era in the study of malaria was initiated. This discovery of malarial organisms and the subsequent experimental proof by a series of workers that they were the etiological agents of the disease failed, however, to lead to the immediate successful cultivation of the parasit...

BACKGROUND MicroRNAs are endogenously expressed, small non-coding RNAs that modulate gene expression by targeting specific mRNAs, resulting in translational repression or mRNA degradation. Although miR-584-5p has been reported to play a vital role in various malignancies, its role and the molecular mechanisms underlying the effects of miR-584-5p in gastric cancer (GC) remain to be clarified. In...

Here, we report that microRNA-584-3p (miR-584-3p) is up-regulated in hypoxic glioma cells and in high-grade human glioma tumors (WHO grades III-IV) relative to normoxic cells and to low-grade tumors (WHO grades I-II), respectively. The postoperative survival time was significantly prolonged in the high-grade glioma patients with high miR-584-3p expression compared with those with low miR-584-3p...

FK584[(-)-N-tert-butyl-4,4-diphenyl-2-cyclopentenylamine hydrochloride, (-)-4-HCl], a potential candidate for the treatment of overactive detrusor, was synthesized in a 4-step approach starting with Sharpless oxidation of cyclopentenol 6 (kinetic resolution). This epoxidation is a rare case in that the empirical rule does not work. Regio- and stereoselective introduction of tert-butylamine to t...

BACKGROUND Resistance to imatinib is an important clinical issue in the treatment of Philadelphia chromosome-positive leukemias which is being tackled by the development of new, more potent drugs, such as the dual Src/Abl tyrosine kinase inhibitors dasatinib and bosutinib and the imatinib analog nilotinib. In the current study we describe the design, synthesis and biological properties of an im...