Microdialysis was used to measure the effect of benzodiazepines (BDZs) on basal levels and on stress-induced increases of 5 -hydroxytryptamine (5 -HT), 5 - hydroxyind oleacetic acid (5 -HIAA) , noradrenaline (NA), and dihydroxyphenylacetic acid (DOP AC). The stressors used were a 5 min tail pinch or a 10 min period of restraint. A subcutaneous injection of 5 mg/kg diazepam decreased basal ...

microdialysis was used to measure the effect of benzodiazepines (bdzs) on basal levels and on stress-induced increases of 5 -hydroxytryptamine (5 -ht), 5 - hydroxyind oleacetic acid (5 -hiaa) , noradrenaline (na), and dihydroxyphenylacetic acid (dop ac). the stressors used were a 5 min tail pinch or a 10 min period of restraint. a subcutaneous injection of 5 mg/kg diazepam decreased basal level...

OBJECTIVES Central serotonergic dysfunction is reported in major depressive disorder (MDD). Serotonin is primarily metabolized to 5-hydroxyindole acetic acid (5-HIAA) and its plasma, urinary or cerebrospinal fluid concentrations were extensively studied in depression. No data is available on salivary 5-HIAA (s5-HIAA) in MDD to date. METHODS The basal, non-stimulated s5-HIAA concentration was ...

OBJECTIVES 5-Hydroxyindoleacetic acid (5-HIAA) is used for the evaluation of neuroendocrine tumors (NETs) but currently requires a 24-hour urine collection. METHODS We developed a gas chromatography mass spectroscopy-based plasma 5-HIAA assay. We compared 24-hour urine 5-HIAA values against plasma 5-HIAA values in 115 mixed-variety patients with NETs and in a subset of 72 patients with only s...

In rhesus macaque males, lower than average cerebrospinal fluid (CSF) concentrations of the principle metabolite of serotonin, 5-hydroxyindoleacetic acid (5-HIAA), have been linked to impulsivity, involvement in escalated aggression, failure to elicit consort relationships, production of fewer sperm plugs, and a relatively early age of mortality. Given these potential fitness costs, we performe...

OBJECTIVE Serotonin mediates vasoconstriction and induces the activation of platelets, which may promote atherosclerosis. The aim of this study was to investigate whether plasma 5-hydroxyindole-3-acetic acid (5-HIAA; a derivative end product of serotonin) concentrations are high in subjects with metabolic syndrome (MetS) and to investigate the relationship between plasma 5-HIAA concentrations a...

AIM Urinary ethyl glucuronide (EtG), ethyl sulfate (EtS), and the ratio between 5-hydroxytryptophol-glucuronide and 5-hydroxyindole-3-acetic acid (GTOL/5-HIAA) are all suggested as biomarkers for recent alcohol ingestion with longer detection times than measurement of ethanol itself. The aim of this controlled study was to compare the sensitivities and detection times of EtG, EtS, and GTOL/5-HI...