Reactions of benzoylpyruvate with a mixture of aromatic aldehydes and 5-amino-1,3,4-thiadizole-2-thiol in a 1:1:1 molar ratio, afforded 5-(5-aryl-4-benzoyl-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-1,3,4-thiadizole-2-thiols (3a-c). The structure of the resulted products was confirmed by determination of the melting point and spectrophotometric techniques such as IR and 1H-NMR spectroscopy.

Keywords: 5-amino-1,3,4-thiadiazole-2-thiol derivatives, diuretic activity, saluretic/natriuretic/carbonic anhydrase inhibition indexes, SAR,

Using environmentally friendly conditions, the nucleophilic ring-opening reaction of 6-azabicyclo[3.1.0]hex-3-en-2-ol with 1-methyl-1H-tetrazole-5-thiol provided a novel thiol-incorporated aminocyclopentitol, (1R,4S,5S)-5-((3-hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol, in excellent yield (95%). The newly synthesized compound was analyzed and characterized via 1H...

Novel structured thiadiazole-attached carbon nitrides are first synthesized via sintering 5-amino-1,3,4-thiadiazole-2-thiol, demonstrating excellent performances towards photocatalytic H 2 evolution under visible light irradiation.

The green synthesis of 5-(4-aminophenyl)-4-aryl-4H-1,2,4-triazole-3-thiol was achieved in four steps, In first step, 4-amino benzoic acid refluxed in ethanol along with catalyst Conc. Sulphuric acid to produce ethyl-4-amino benzoate I. Further compound I refluxed with hydrazine hydrate in ethanol to produce 4-amino benzohydrazide II. Compound II refluxed in ethanolic potassium hydroxide with ca...

Abstract A series of new quinazoline-4(3H)-one derivatives (2-16) have been synthesized using methyl α-[(4-oxoquinazolin-2-yl)thio]acetate (1) as precursor. The corresponding hydrazide (2) and thiosemicarbazide (4) were from this ester via the reaction with hydrazine hydrate ammonium thiocyanate respectively. was employed to synthesize 2-amino-1,3,4-thiadiazole (5) 1,3,4-triazole-5-thiol (6) it...