نتایج جستجو برای: 491

تعداد نتایج: 2551  

2016
Gernot Marx Achim W. Schindler Christoph Mosch Joerg Albers Michael Bauer Irmela Gnass Carsten Hobohm Uwe Janssens Stefan Kluge Peter Kranke Tobias Maurer Waltraut Merz Edmund Neugebauer Michael Quintel Norbert Senninger Hans-Joachim Trampisch Christian Waydhas Rene Wildenauer Kai Zacharowski Michaela Eikermann

Index Table of contents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 489 List of abbreviations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 489 A. Rationale and goals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

2014
Xingrong Liu Jonathan Cheong Xiao Ding Gauri Deshmukh

The study objectives were 1) to test the hypothesis that the lack of P-glycoprotein (P-gp) and the inhibition of breast cancer resistance protein (Bcrp) at the blood-brain barrier after cassette dosing of potent P-gp and Bcrp inhibitors were due to low plasma concentrations of those inhibitors and 2) to examine the effects of P-gp on the unbound brain (Cu,brain) and cerebrospinal fluid (CSF) co...

Journal: :Pediatric Critical Care Medicine 2018

2016
Janette Y. Berg Erin Osborne Nishimura AdamG. Robinson Barbara Goszczynski Jason D. Lieb James D. McGhee

ELT-2 is the major regulator of genes involved in differentiation, maintenance and function of C. elegans intestine from the early embryo to mature adult. elt-2 responds to overexpression of the GATA transcription factors END-1 and END-3, which specify the intestine, as well as to overexpression of the two GATA factors that are normally involved in intestinal differentiation, ELT-7 and ELT-2 it...

2002

The Convention on Biological Diversity (CBD) was one of two legally binding treaties that were put out for signing at the Rio Summit in 1992. More than 180 nations have ratified the Convention so far. The signatories to the Convention are obliged to set up legislation and regulations to meet the objectives of the CBD, these being i) the conservation of biodiversity, ii) the sustainable use of i...

2016
Zengxin Qi Shengyong Cai Jiajun Cai Lingchao Chen Yu Yao Liang Chen Ying Mao

BACKGROUND MicroRNAs are significantly involved in tumorigenesis and progression of glioma. However, the critical part they play in glioma have not been fully elaborated. miR-491 and Tripartite motif containing 28 (TRIM28) are reported to aberrantly express in glioblastoma multiforme (GBM). Here, we detected miR-491 and TRIM28 expression and function in glioma cells. METHODS We analyzed miR-4...

2017
Zhiyuan Wang Chao Jiang Xiaobo Chang Yahui Dai

Osteosarcoma is one of the most leading causes of cancer-related mortality in children and adolescence around the world. The aim of this study was to determine the clinical value of miR-491-5p in osteosarcoma. Quantitative real-time PCR was used to evaluate miR-491-5p level in the tissue/serum samples from patients with osteosarcoma. Then the clinical significance of tissue/serum miR-491-5p was...

2015
Guopei Zheng Xiaoting Jia Cong Peng Yingen Deng Jiang Yin Zhijie Zhang Nan Li Min Deng Xiaorong Liu Hao Liu Minying Lu Chengkun Wang Yixue Gu Zhimin He

We found that levels of miR-491-3p were decreased in multidrug-resistant tongue cancer (TC) cells. Induction of miR-491-3p expression sensitized TC cells to chemotherapy. In agreement, functional inhibition of miR-491-3p enhanced resistance of TC cells to chemotherapy. We found that miR-491-3p directly targeted mTORC2 component Rictor and inhibited mTORC2 activity, which was increased in resist...

Journal: :Molecular therapy : the journal of the American Society of Gene Therapy 2017
Shu-Nan Wang Song Luo Chang Liu Zhenghao Piao Wenlong Gou Yun Wang Wei Guan Qing Li Hua Zou Zhen-Zhou Yang Dong Wang Yan Wang Meng Xu Hua Jin Cheng-Xiong Xu

Dysregulated microRNAs (miRNAs) play an important role in osteosarcoma (OS) progression. In the present study, we investigate the clinical significance of serum miR-491 level and the potential role of miR-491 in OS lung metastasis and chemoresistance. Clinical data show that the level of miR-491 was decreased in serum from OS patients compared with healthy control subjects, and that a decreased...

2007
Cristina SANCHES Karin V. LÓPEZ Celia E. OMOSAKO Maria A. BERTOLINE Maria D. PEREIRA

A simple, rapid, selective and sensitive analytical method by HPLC with UV detection was developed for the quantification of carbamazepine, phenobarbital and phenytoin in only 0.2 mL of plasma. A C18 column (150 x 3.9 mm, 4 micra) using a binary mobile phase consisting of water and acetonitrile (70:30, v/v) at a flow rate of 0.5 mL/min were proposed. Validation of the analytical method showed a...

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