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Ischaemic stroke is the leading cause of severe long-term disability yet lacks drug therapies that promote the repair phase of recovery. This repair phase of stroke occurs days to months after stroke onset and involves brain remapping and plasticity within the peri-infarct zone. Elucidating mechanisms that promote this plasticity is critical for the development of new therapeutics with a broad ...
The Complexity of Economic Policy: I. Restricted Local Optima in Tax Policy Design Economists traditionally tackle normative problems by computing optimal policy, i.e. the one that maximizes a social welfare function. In practice, however, a succession of marginal changes to a limited number of policy instruments are implemented, until no further improvement is feasible. I call such an outcome ...
High resolution melting (HRM) is a novel, closed-tube, post-PCR technique allowing genomic researchers to easily analyze genetic variations in PCR amplicons. This technical note describes general steps of setting up HRM-based PCR assays, with a special focus on ways how to optimize procedures for gene scanning experiments. The novel High Resolution Melting (HRM) technique enables researchers to...
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that mediates both NADH-oxidizing and caspase-independent apoptosis. Further, the proapoptotic activity of AIF is located in the C-terminus of AIF, although the precise minimum sequence responsible for apoptosis induction remains to be investigated. In the present study, we generated two truncated AIFs, AIFDelta1-480-FLAG, which is...
data parallelism for a decision tree, 489–492 data set structure, 479–480 decision tree algorithm, 480–481 decision tree classification, 477–480 processes, 480–488 structure, 478–479 result parallelism for the decision tree, 492–495
We report on the detection of a thermal disc component from the stellar-mass black hole binary XTE J1118+480 in the canonical low/hard state. The presence of a thermal component with a temperature of approximately 0.21 keV in the Chandra spectra of XTE J1118+480 is found at more than the 14σ confidence level. Based on this evidence, we argue that the accretion disc in XTE J1118+480 is not trunc...
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