The widespread human exposure to bisphenol A (BPA), an endocrine disruptor targeting developmental processes, underlines the need to better understand the mechanisms of fetal exposure. Animal studies have shown that at a late stage of pregnancy BPA is efficiently conjugated by the fetoplacental unit, mainly into BPAglucuronide (BPA-G), which remains trapped within the fetoplacental unit. Fetal ...

Background: Weight loss may improve glucose control in persons with type 2 diabetes. The effects of fat quality, as opposed to quantity, on weight loss are not well understood. Objective: We compared the effects of 2 dietary oils, conjugated linoleic acid (CLA) and safflower oil (SAF), on body weight and composition in obese postmenopausal women with type 2 diabetes. Design: This was a 36-wk ra...

The mammalian suprachiasmatic nucleus (SCN) is a master circadian pacemaker. It is not known which SCN neurons are autonomous pacemakers or how they synchronize their daily firing rhythms to coordinate circadian behavior. Vasoactive intestinal polypeptide (VIP) and the VIP receptor VPAC2 (encoded by the gene Vipr2) may mediate rhythms in individual SCN neurons, synchrony between neurons, or bot...

Unraveling the mechanisms underlying early neural differentiation of embryonic stem cells (ESCs) is crucial to developing cell-based therapies of neurodegenerative diseases. Neural fate acquisition is proposed to be controlled by a ‘default’ mechanism, for which the molecular regulation is not well understood. In this study, we investigated the functional roles of Mediator Med23 in pluripotency...

Previous studies have indicated that situational context impacts the rapport experience (e.g., F. J. Bernieri, J. S. Gillis, J. M. Davis, & J. E. Grahe, 1996; N. M. Puccinelli, L. Tickle-Degnen, & R. Rosenthal, 2003). The authors designed the present study to further document the behavioral and experiential predictors of dyadic rapport and to evaluate dyadic rapport experiences when contributio...

© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinhei G. Y. Margulis Department of Applied Physics Stanford University Geballe Laboratory for Advanced Materials 476 Lomita Mall, Stanford, CA, 94305, USA M. G. Christoforo Department of Electrical Engineering Stanford University Geballe Laboratory for Advanced Materials 476 Lomita Mall, Stanford, CA, 94305, USA D. Lam Department of Physics Stanford Un...

Background Many extrapulmonary neoplasms metastasize to the lungs. We conducted a retrospective review of all patients who underwent pulmonary metastasectomy for oligometastatic disease at two centres in order determine long-term outcomes. Methods The study institutions' thoracic surgery databases were searched from 2000 2017. Results There total 476 metastasectomy. Mean age time was 57.2 ± 15....