نتایج جستجو برای: 450 inhibition

تعداد نتایج: 351106  

Journal: :iranian journal of pharmaceutical sciences 0
hossein niknahad pharmaceutical sciences research center, and school of pharmacy, shiraz university of medical sciences, shiraz, iran. peter j. o brien faculty of pharmacy, university of toronto, toronto, ontario, canada

it has been proposed that organic nitrates such as glyceryl trinitrate (gtn), used in the treatment of cardiovascular diseases, act by producing nitric oxide (no). however, the biochemical pathway for no formation from gtn is not well understood. in the present study, we showed that nitrate formation from gtn, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione was de...

Journal: :iranian journal of pharmaceutical sciences 0
hossein niknahad faculty of pharmacy, shiraz university of medical sciences, shiraz, fars, iran, 71345 peter j. o’ brien faculty of pharmacy, university of toronto, toronto, ontario, canada, m5s 2s2

addition of n-butyl nitrite to isolated rat hepatocytes caused an immediate glutathione depletion followed by an inhibition of mitochondrial respiration, inhi- bition of glycolysis and atp depletion. at cytotoxic butyl nitrite concentrations, lipid  peroxidation  occurred  before  the  plasma  membrane  was  disrupted. cytochrome p-450 inhibitors inhibited peroxynitrite formation and prevented ...

Hossein Niknahad, Peter Brien

      Addition of n-butyl nitrite to isolated rat hepatocytes caused an immediate glutathione depletion followed by an inhibition of mitochondrial respiration, inhi- bition of glycolysis and ATP depletion. At cytotoxic butyl nitrite concentrations, lipid  peroxidation  occurred  before  the  plasma  membrane  was  disrupted. Cytochrome P-450 inhibitors inhibited peroxynitrite formation and prev...

Journal: :Cancer research 1981
E Hara K Kawajiri O Gotoh Y Tagashira

The roles of two species of cytochrome P-450, the major cytochrome P-450 components of liver microsomes of phenobarbital-treated rats (PB-P-450) and of 3-methylcholanthrenetreated rats (MC-P-448), in the metabolism of 2-acetylaminofluorene were studied in rat liver microsomes in vitro. 2-Acetylaminofluorene was incubated with the microsomes of rats treated with three different inducers of monoo...

2000
JEFFERSON C. FRISBEE JOHN R. FALCK JULIAN H. LOMBARD

Frisbee, Jefferson C., John R. Falck, and Julian H. Lombard. Contribution of cytochrome P-450 v-hydroxylase to altered arteriolar reactivity with high-salt diet and hypertension. Am J Physiol Heart Circ Physiol 278: H1517–H1526, 2000.—The present study evaluated the contribution of cytochrome P-450 v-hydroxylase in modulating the reactivity of cremaster muscle arterioles in normotensive rats on...

Journal: :British Journal of Clinical Pharmacology 1986

Journal: :American journal of physiology. Heart and circulatory physiology 2000
J C Frisbee J R Falck J H Lombard

The present study evaluated the contribution of cytochrome P-450 omega-hydroxylase in modulating the reactivity of cremaster muscle arterioles in normotensive rats on high-salt (HS) and low-salt (LS) diet and in rats with reduced renal mass hypertension (RRM-HT). Changes in arteriolar diameter in response to ACh, sodium nitroprusside (SNP), ANG II, and elevated O(2) were measured via television...

Journal: :Cancer research 1982
S S Park T Fujino D West F P Guengerich H V Gelboin

Somatic cell hybrids were made between mouse myeloma cells and spleen cells derived from BALB/c mice immunized with liver microsomal cytochrome P-450 purified from rats treated with 3-methylcholanthrene (MC-P-450). Thirty-seven independent hybrid clones among 66 tested produced mono clonal antibodies to the MC-P-450 as measured by radioimmunoassay. More than 10 of the monoclonal antibodies form...

Journal: :Journal of steroid biochemistry 1985
M C Tobes S J Hays D L Gildersleeve D M Wieland W H Beierwaltes

The adrenal cortical enzyme systems, 11 beta-hydroxylase, P-450 11 beta, and the side-chain cleavage complex, P-450 scc, differ only in their cytochrome P-450s. Structural modifications of metyrapone, an inhibitor of cytochrome P-450 enzyme systems, have been made to determine the requirement for the A- or B-pyridyl ring for inhibition of P-45011 beta and P-450 scc activities. Three new analogs...

Journal: :The Journal of biological chemistry 1974
E A Thompson P K Siiteri

The aromatization of androstenedione is inhibited in the presence of aminoglutethimide, diethylaminoethyl-2,2-diphenyl valerate HCl (SKF 525-A), and 1W3 M KCN, but not carbon monoxide or metyrapone. The role of cytochrome P-450 in this reaction could not, therefore, be unequivocally established by inhibition studies. However, it was determined that steroid binding to placental microsomal cytoch...

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