Music and speech are very cognitively demanding auditory phenomena generally attributed to cortical rather than subcortical circuitry. We examined brainstem encoding of linguistic pitch and found that musicians show more robust and faithful encoding compared with nonmusicians. These results not only implicate a common subcortical manifestation for two presumed cortical functions, but also a pos...

The challenge of devising a set of biomarkers capable of measuring the ageing rate in human subjects was articulated long ago. In recent years, progress in the basic biology of ageing suggests the realistic possibility of preventive or restaurative interventions that may extend healthy lifespan in mammals including human subjects. Specifically, frailty is being increasingly recognised as a clin...

G protein–coupled receptors (GPCRs) regulate a wide variety of physiological functions in response to structurally diverse ligands ranging from cations and small organic molecules to peptides and glycoproteins. For many GPCRs, structurally related ligands can have diverse efficacy profiles. To investigate the process of ligand binding and activation, we used fluorescence spectroscopy to study t...

Angiosperm ovules consist of three proximal-distal domains – the nucellus, chalaza and funiculus – demarcated by developmental fate and specific gene expression. Mutation in three paralogous class III homeodomain leucine zipper (HD-ZIPIII) genes leads to aberrations in ovule integument development. Expression of WUSCHEL (WUS) is normally confined to the nucellar domain, but in this triple mutan...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 185 No. 3 409–422 www.jcb.org/cgi/doi/10.1083/jcb.200804038 JCB 409 Correspondence to Paul A. Khavari: [email protected] Abbreviations used in this paper: CA, constitutively active; Erk, extracellular signal-regulated kinase; GO, gene ontology; PI, propidium iodide; Mek, MAPK/ Erk kinase; Rsk, ribosomal S6 kinase; WT, wild type. Intr...

(51) Int. Cl. B03C1102 (2006.01) C12M 1/00 (2006.01) (52) U.S. Cl. USPC ................... 210/222; 252/62.51 R; 422/68.1; 422/502; 422/504; 422/527; 435/287.2; 435/308.1; 436/526; 436/806 (58) Field of Classification Search USPC ........... 210/222; 252/62.51 R; 422/68.1, 502, 422/504, 527; 435/287.2, 308.1; 436/526, 436/806 See application file for complete search history. (1o) Patent No.: U...

─The purpose of this study was to explore the related practical techniques of monitoring and controlling system in designing renewable energy system, especially for Small-scaled wind-power generator. Recently, the whole world was actively developing replaced energy to solve the economic development and daily-life necessities problems resulting from gradually lacking of oil. Taiwan government wa...

Stannosis, kalay (tin-oksid/stannik oksid) toz ve buhar inhalasyonunun sonucu olarak kalayın pulmoner parankimde biriktiği fibrotik olmayan bir pnömokonyozdur. Göğüs radyografisinde her iki akciğerde çok sayıda ve dens nodüller vardır. Stannozisin radyolojik bulgularının aşikar olmasına rağmen hastalar klinik olarak iyi durumdadır ve solunum fonksiyon testi değerlerinde sapma yoktur. Dört yıldı...