Allergic reactions to mannitol have been reported rarely, despite its widespread use as a drug and as a food excipient. This is the first case report in which oral mannitol induces an immediate type hypersensitivity as a drug excipient, in a 42 year old man affected by rhinitis to olive tree pollen. Unusual and undervalued risk factors for mannitol hypersensitivity are examined.

Superficial transitional cell carcinomas (TCC) account for about 70% of all bladder cancers in North America and Europe [1]. Following surgery, these tumours recur in more than 60% of cases and up to 25% of recurrences become invasive. For more than 20 years, intravesical bacillus Calmette-Guérin (BCG) instillation has been used successfully to prevent recurrence and progression of superficial ...

The acridinone derivates 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8hydroxyimidazoacridinone (C-1311) are promising antitumor agents with high activity against several experimental cellular and tumor models and are under evaluation in preclinical and early phase clinical trials. Recent evidence from our laboratories has indicated that both comp...

– We analyzed skins and skulls of chevrotains (Moschiola sp., Artiodactyla) from Sri Lanka and India, and found considerable differences within this taxon. Based on the consistency of these differences we concluded that this taxon can be divided into three species: Moschiola indica from southern India, M. meminna from the Dry Zone in Sri Lanka, and M. kathygre n. sp. from Sri Lanka’s Wet Zone. ...

Age-related macular degeneration (AMD) is a complex neurodegenerative visual disorder that causes profound physical and psychosocial effects.Visual impairment inAMD is causedby the lossof retinal pigmented epithelium (RPE) cells and the light-sensitive photoreceptor cells that they support. There is currently no effective treatment for the most common form of this disease (dry AMD). A new appro...

MicroRNAs might act as oncogenes or tumor suppressors in cancer. Recent studies have shown that miR-421 is up-regulated in human gastric cancer. Here, we found that miR-421 was over-expressed in gastric cancer tissues and cell lines. Bioinformatics analysis predicted that the caspase-3 gene was a target of miR-421. Caspase-3 was negatively regulated by miR-421 at the post-transcriptional level....

Antibodies to DNA are important markers of various autoimmune diseases and can be pathogenic; however, their generation is not understood. We previously reported that anti-DNA antibodies could be induced in mice by idiotypic immunization to PAb-421, an antibody to a DNA-binding domain of p53. We now report that two monoclonal antibodies of moderate affinity (K(D) asymptotically equal to 10(-7))...