We made substantial advances in the implementation of a rapamycin-triggered heterodimerization strategy. Using molecular engineering of different targeting and enzymatic fusion constructs and a new rapamycin analog, Rho GTPases were directly activated or inactivated on a timescale of seconds, which was followed by pronounced cell morphological changes. As signaling processes often occur within ...

Sir, Since the initial reports of vancomycin-resistant enterococci (VRE) in the late 1980s, increasing numbers of such isolates have been identified in centres in both Europe and the U S A . , 2 In 1998, Fujita et al. were the first authors in Japan to describe the isolation of a vancomycin-resistant strain of Enterococcus faecium from a patient with a urinary tract infection. To date, 10 strai...

The concepts in this course will center on the physiology of membranes and of excitable cells. Please approach this field of study with the point of view that the cell membrane is a highly dynamic, structured, complex organelle, subject to the same physical laws as is any other structure. Cell membranes are probably responsible for more tasks than any other organelle. Such tasks include mainten...

The absorption, metabolism, and excretion of darapladib, a novel inhibitor of lipoprotein-associated phospholipase A2, was investigated in healthy male subjects using [C]-radiolabeled material in a bespoke study design. Disposition of darapladib was compared following single i.v. and both single and repeated oral administrations. The anticipated presence of low circulating concentrations of dru...

Using 68Ge : 14C dual-labeling, we investigated the absorption efficiency of diatom carbon for the cold water appendicularian Oikopleura vanhoeffeni. The absorption efficiency of bulk carbon (mean 5 67%) was not influenced by body size or ingestion rate. For the first time for a pelagic tunicate, food and feces were fractionated into their major biochemical constituents (i.e., low-molecular-wei...

Increasing demand for wireless mobile communications, coupled with limited network resources, has motivated investigation into alternative e cient mobility management solutions. In this paper, we consider wireless PCS call setup protocols. We propose a Lightweight Location Lookup Protocol, which signi cantly reduces the network signaling and setup delay during call setup. As an alternative, we ...

INTRODUCTION .......................................... 403 COLOR VISION .......................................... 405 RED AND GREEN PIGMENTS ................................. 406 Psychophysics of Red~Green Color Blindness ....................... 406 Molecular Genetics of RedIGreen Color Blindness .................... 407 Variation in Normal Color Vision .............................. 409 Blue...

David J Quan1† & Marion G Peters2 †Author for correspondence 1Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, 521 Parnassus Avenue, Room C-152, Box 0622, San Francisco, CA 94143-0622, USA Tel.: +1 415 353 1462; Fax: +1 415 353 1240; E-mail: david.quan@ ucsfmedctr.org 2Division of Gastroenterology, University of California, San Francisco, 513 Parnass...