The main objective of this work is to characterize the rheological behavior of poloxamer 407 solutions and gels in various shear flow fields.

We investigate a lattice Nambu–Jona-Lasinio model both by the Monte Carlo method and Schwinger-Dyson equations. A comparison allows the discussion of finite size effects and the extrapolation to infinite volume. We pay special attention to the identification of particles and resonances. This enables us to discuss renormalisation group flows in the neighbourhood of the critical coupling where th...

Macromolecular SymposiaVolume 407, Issue 1 2370001 Cover PictureFree Access Macromol. Symp. 407 First published: 23 February 2023 https://doi.org/10.1002/masy.202370001AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions of Use check box below share version article.I have read a...

Macromolecular SymposiaVolume 407, Issue 1 2370003 InformationFree Access Title Page 407 First published: 23 February 2023 https://doi.org/10.1002/masy.202370003AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions of Use check box below share version article.I have read accept t...

In bacterial chemotaxis, an assembly of transmembrane receptors, the CheA histidine kinase and the adaptor protein CheW processes environmental stimuli to regulate motility. The structure of a Thermotoga maritima receptor cytoplasmic domain defines CheA interaction regions and metal ion–coordinating charge centers that undergo chemical modification to tune receptor response. Dimeric CheA–CheW, ...

The copolymer surfactant poloxamer 407 (P-407) has been used to induce a dose-controlled dyslipidaemia in both mice and rats. Human macrophages cultured with P-407 exhibit a concentration-dependent reduction in cholesterol efflux to apolipoprotein A1 (apoA1) due to down-regulation of the ATP-binding cassette transporter A1 (ABCA1). Peroxisome proliferator-activated receptor alpha (PPARalpha) ca...

The toxicity of preservatives on conjunctival epithelium has been widely described in glaucomatous patients topically treated, suggesting both an indirect effect on the lacrimal film and a direct toxic action on epithelial cells (1). Previous studies indicate that long-term administration of preservative-containing eyedrops can lead to chronic conjunctival inflammation, ocular surface impairmen...

Hepatocytes provide an integrated model to study drug metabolism and disposition. As a result of a loss of polarity or a significant decrease in the expression of enzymes and transporters, suspended and sandwich-cultured hepatocytes have limitations in determining hepatocellular drug concentrations. Underprediction of the extent of glucuronidation is also a concern for these hepatocyte models. ...