the apoptotic protease-activating factor 1 (apaf-1) receives the death signal in the intrinsic ormitochondrial pathway of apoptosis. upon the releasing of cytochrome c from theintermembrane space of mitochondria and binding to apaf-1 molecules, a heptamericapoptosome complex is formed and triggers the downstream cascade of caspases. here, for thefirst time we present spontaneous mutations and r...

Background Androgen receptor (AR) mediates androgen actions such as initiation and promotion of spermatogenesis and growth of accessory sex organs. There are two trinucleotide polymorphisms (CAG and GGN repeats) in exon1 of AR gene that are vary in length in population. The CAG and GGN repeats association with infertility is still unknown and this study is planned to assess the distribution of ...

results a number of 7-11 repeats in the spa gene xr region were determined. strains with 10 repeats were65%, therefore they had the highest percentage in isolates. seven repeats strains were 20% and each of the strains with 8, 9 and 11 repeats had the frequency of 5%. s. aureus strains antibiotic resistance was 35%, 5%, 45% and 40% for tetracycline, amoxicillin, gentamicin and erythromycin resp...

Although genetic and environmental factors have been identified in the etiology of thyroid cancer, the specific genetic implications in sporadic thyroid tumors are poorly understood but, as in other common cancers, low-penetrance susceptibility genes are believed to be crucial in the tumorigenesis processes. Here, we have carried out a case-control study to investigate whether there is an assoc...

Background s:648:"The infertility has recently been estimated to affect approximately 9% of couples worldwide. Androgens and a functional androgen receptor (AR) are essential for normal development of the male gender, and for maintenance of spermatogenesis throughout the life. Two polymorphic trinucleotide repeats, CAG and GGN, encoding for the amino acids glutamine and glycine, respectively ar...

Background: The lengths of CAG repeats in two spinocerebellar ataxia genes, SCA1 and SCA3, were analyzed to determine whether such repeats exist in higher numbers in infertile males. Materials and Methods: Blood samples were collected from healthy controls, oligozoospermia patients, and azoospermia patients. DNA fragments containing target CAG repeats were amplified by PCR with template DNA pur...

Eight severe inherited neurodegenerative diseases are caused by expansion of glutamine repeats in the affected proteins. In every case, proteins with repeats of fewer than 38 glutamine residues are harmless, but those with repeats of more than 41 glutamine residues form toxic neuronal nuclear aggregates in the affected neurons. Similarly, proteins that have repeats of fewer than 37 glutamine re...

Abstract More than 40 human diseases, mainly diseases affecting the central nervous system, are caused by expansion of unstable nucleotide repeats. Repeats sequences like (CAG)n present in different genes can be responsible for various system. An expanded hexanucleotide repeat (GGGGCC)n C9ORF72 gene has been characterized as most frequent genetic cause amyotrophic lateral sclerosis and frontote...

dna typing is a new method with important applications in forensic medicine. in the present study, we evaluated application of dna typing in iran. loci hum lpl, hum tpox, hum f13, hum vw 31a, hum th01 and hum fes/fps of dna short tandem repeats were studied. to determine sensitivity of the test, 85 mother-child couples (1020 chromosomes) that were referred to dna section of legal medicine organ...