A series of linear coordination polymers, metallacycles of cadmium(II) and mercury(II) of flexible carboxylic acid ligands, RCH{3-CH(3)-,5-CH(3)-,6-(-OCH(2)CO(2)H)C(6)H(2)}(2), (when R = C(6)H(5), (H(2)L(1)); 2-NO(2)C(6)H(4)- (H(2)L(2)) and 3-NO(2)C(6)H(4)- (H(2)L(3))) are synthesized and characterized. [CdL(1) (py)(3)](n)·3nH(2)O (py = pyridine) is a linear coordination polymer, whereas [CdL(2...

An alternative strategy for the synthesis of 1-aryl- and 1-alkyl-2-methylsulfanyl-4-(4-fluorophenyl)-5-(pyridin-4-yl)imidazoles as potential p38α mitogen-activated protein kinase inhibitors is reported. The regioselective N-substitution of the imidazole ring was achieved by treatment of α-aminoketones with different aryl or alkyl isothiocyanates. In contrast to previously published synthesis ro...

Interactions of neutral pyridine ligands and anionic benzoate with the metalloporphyrin walls M6L3 nanocages (M = [(tmeda)Pt]2+, L tetra(3-pyridyl)porphyrin-M′, M′ CoII, Co3-1; ZnII, Zn3-1) were evaluated in CD3CN. The binding to simple tetra(N-methyl-3-pyridinium)porphyrin-M′ complexes Co-2 Zn-2 was also evaluated. It found that bind generally similar strength monomeric porphyrins as outer fac...

Six 3-methylpyridine zwitterions and six quinoline zwitterions were synthesized through the reaction of 4-hydroxycoumarins, p-benzoquinone and the corresponding N-aromatics. The novel pseudo-cyclic face-to-face rigid structure of the zwitterion was elucidated by (1)H-NMR at different temperatures, and assumed to be caused by both the intramolecular ion pair attraction and the steric interaction.

An optimized strategy for the synthesis of the potent p38α mitogen-activated protein kinase inhibitors 2-(2-hydroxyethylsulfanyl)-4-(4-fluorophenyl)-5-(2-aminopyridin-4-yl)imidazole (3) and 2-(2,3-dihydroxypropylsulfanyl)-4-(4-fluorophenyl)-5-(2-aminopyridin-4-yl)imidazole (4) starting from 2-fluoro-4-methylpyridine is reported. In contrast to a previously published synthesis starting from 2-br...

Cells of Gordonia nitida LE31 grown on 3-methylpyridine degraded 3-ethylpyridine without a lag time and vice versa. Cyclic intermediates were not detected, but formic acid was identified as a metabolite. Degradation of levulinic acid was induced in cells grown on 3-methylpyridine and 3-ethylpyridine. Levulinic aldehyde dehydrogenase and formamidase activities were higher in cells grown on 3-met...