This study is the first report of numerical solution of nonlinear bending analysis for annular and circular plates based on 3D elasticity theory with asymmetric boundary conditions using semi-analytical polynomial method (SAPM). Orthotropic annular and circular plates are subjected to transverse loading and 3D bending analysis in the presence of symmetric and asymmetric boundary conditions is s...

We search in this paper for context-specific modes of three-dimensional (3D) cell migration using imaging for phosphatidylinositol (3,4,5)-trisphosphate (PIP3) and active Rac1 and Cdc42 in primary fibroblasts migrating within different 3D environments. In 3D collagen, PIP3 and active Rac1 and Cdc42 were targeted to the leading edge, consistent with lamellipodia-based migration. In contrast, elo...

Magnetic resonance elastography (MRE) is an important new method used to measure the elasticity or stiffness of tissues in vivo. While there are many possible applications of MRE, breast cancer detection and classification is currently the most common. Several groups have been developing methods based on MR and ultrasound (US). MR or US is used to estimate the displacements produced by either q...

Studying mechanobiology in three-dimensional (3D) cell cultures better recapitulates cell behaviors in response to various types of mechanical stimuli in vivo Stiffening of the extracellular matrix resulting from cell remodeling potentiates many pathological conditions, including advanced cancers. However, an effective tool for measuring the spatiotemporal changes in elastic properties of such ...

The use of platelet-rich plasma and growth factors is emerging as an anti-ageing regimen for the skin. We tested the safety and efficacy of 3D-MatrixLift®, a new treatment regimen for skin rejuvenation that combines medical needling and the application of a stem cell and growth factor-rich solution with irradiation by LED light. A total of 15 participants were enrolled in a single-centre, prosp...

We present a model for disordered 3D fiber networks to study their linear and nonlinear elasticity. In contrast to previous 2D models, these 3D networks with binary crosslinks are underconstrained with respect to fiber stretching elasticity, suggesting that bending may dominate their response. We find that such networks exhibit a bending-dominated elastic regime controlled by fiber length, as w...