نتایج جستجو برای: 3beta

تعداد نتایج: 1660  

Journal: :hepatitis monthly 0
christine hartoonian department of pharmaceutical biotechnology and biotechnology research center, faculty of pharmacy, tehran university of medical sciences, tehran, ir iran; department of virology, pasteur institute of iran, tehran, ir iran zargham sepehrizadeh department of pharmaceutical biotechnology and biotechnology research center, faculty of pharmacy, tehran university of medical sciences, tehran, ir iran; department of pharmaceutical biotechnology and biotechnology research center, faculty of pharmacy, tehran university of medical sciences, tehran, ir iran. tel: +98-2164122301, fax: + 98-2166461178, e-mail: kayhan azadmanesh, department of virology, pasteur institute of iran, tehran, ir iran. tel/fax: +98-2166496682 mojtaba tabatabai yazdi department of pharmaceutical biotechnology and biotechnology research center, faculty of pharmacy, tehran university of medical sciences, tehran, ir iran yong suk jang departments of molecular biology and bioactive material sciences, institute for molecular biology and genetics, chonbuk national university, jeonju, korea lida langroudi department of virology, pasteur institute of iran, tehran, ir iran parisa amir kalvanagh department of virology, pasteur institute of iran, tehran, ir iran; department of immunology, faculty of medical sciences, tarbiat modaress university, tehran, ir iran

conclusions these results exhibited the immuno potentiator effects of mip-3beta plasmid when coadministrated with the hcv core dna vaccine. complimentary studies integrating mip-3beta as a genetic adjuvant in hcv-core-dna vaccination models are warranted. results mice covaccinated with mip-3beta elicited an enhanced th1 biased systemic immune response as evidenced by higher ifn-γ/il-4 and anti-...

Journal: :iranian journal of public health 0
a shahbazi a raeisi m nateghpour h mirhendi m mohebali m asmar

background: plasmodium vivax malaria accounts for approximately 88% of malaria cases in iran. there is limited in­formation on genetic diversity of p. vivax in the country and a need to develop and apply an effective vaccine against the dis­ease is necessary. among many potential candidates, msp -3β gene is promising target. this study was designed and car­ried out to determine the variation of...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2007
Cheng-Hui Fang Bingguo Li J Howard James Ayesha Yahya Nijiati Kadeer Xialing Guo Chun Xiao Dorothy M Supp Richard J Kagan Per-Olof Hasselgren Sulaiman Sheriff

Previous reports suggest that burn-induced muscle proteolysis can be inhibited by treatment with GSK-3beta inhibitors, suggesting that burn injury may be associated with increased GSK-3beta activity. The influence of burn injury on muscle GSK-3beta activity, however, is not known. We determined the effect of a 30% total body surface full-thickness burn injury in rats on muscle GSK-3beta activit...

Journal: :Chemical & pharmaceutical bulletin 2000
Y H Kuo Y M Chiang

Four new ursane-type triterpenes, 3beta-acetoxy-11alpha-methoxy-12-ursene (1), 3beta-acetoxy-11alpha-ethoxy-12-ursene (2), 3beta-acetoxy-11alpha-hydroperoxy-12-ursene (3), 3beta-hydroxy-11alpha-hydroperoxy-12-ursene (4), and two new oleanane-type triterpenes, 3beta-acetoxy-11alpha-ethoxy-12-oleanene (5), 3beta-acetoxy-111alpha-hydroperoxy-12-oleanene (6), together with 3beta-acetoxy-11alpha-hyd...

Journal: :Chemical & pharmaceutical bulletin 2003
Lawrence Onyango Arot Manguro Ivar Ugi Peter Lemmen

Fractionation of a steam distilled residue of Commiphora confusa resin has yielded four novel dammarane triterpenes characterised as (20S)-3beta-acetoxy-12beta,16beta-trihydroxydammar-24-ene, (20S)-12beta,16beta-trihydroxydammar-24-ene-3beta-O-beta-glucopyranoside, (20S)-3beta-acetoxy-12beta,16beta,25-tetrahydroxydammar-23-ene, and (20S)-3beta,12beta,16beta,25-pentahydroxydammar-23-ene. The kno...

Journal: :Circulation research 2007
Shinichi Hirotani Peiyong Zhai Hideharu Tomita Jonathan Galeotti Juan Pablo Marquez Shumin Gao Chull Hong Atsuko Yatani Jesús Avila Junichi Sadoshima

Glycogen synthase kinase (GSK)-3, a negative regulator of cardiac hypertrophy, is inactivated in failing hearts. To examine the histopathological and functional consequence of the persistent inhibition of GSK-3beta in the heart in vivo, we generated transgenic mice with cardiac-specific overexpression of dominant negative GSK-3beta (Tg-GSK-3beta-DN) and tetracycline-regulatable wild-type GSK-3b...

Journal: :American journal of physiology. Heart and circulatory physiology 2008
Guillaume Chanoit SungRyul Lee Jinkun Xi Min Zhu Rachel A McIntosh Robert A Mueller Edward A Norfleet Zhelong Xu

The purpose of this study was to determine whether exogenous zinc prevents cardiac reperfusion injury by targeting the mitochondrial permeability transition pore (mPTP) via glycogen synthase kinase-3beta (GSK-3beta). The treatment of cardiac H9c2 cells with ZnCl2 (10 microM) in the presence of zinc ionophore pyrithione for 20 min significantly enhanced GSK-3beta phosphorylation at Ser9, indicat...

Journal: :Plant physiology 1974
J T Chan G W Patterson

When Chlorella sorokiniana was cultured in the presence of 1 mg/1 triparanol succinate, there was a 42% reduction in total sterol concentration. Algal biomass was reduced by approximately the same amount. In addition to the cycloartenol, cyclolaudenol, 24-methyl-pollinastanol, ergosta-5, 7-dien-3beta-ol, and ergosterol that occur in control culture, pollinastanol, 14alpha-methyl-5alpha-ergost-8...

Journal: :Journal of natural products 2008
Chi-I Chang Chiy-Rong Chen Yun-Wen Liao Hsueh-Ling Cheng Yo-Chia Chen Chang-Hung Chou

Four new cucurbitane-type triterpenes, cucurbita-5,23(E)-diene-3beta,7beta,25-triol (1), 3beta-acetoxy-7beta-methoxycucurbita-5,23(E)-dien-25-ol (2), cucurbita-5(10),6,23(E)-triene-3beta,25-diol (5), and cucurbita-5,24-diene-3,7,23-trione (6), together with four known triterpenes, 3beta,25-dihydroxy-7beta-methoxycucurbita-5,23(E)-diene (3), 3beta-hydroxy-7beta,25-dimethoxycucurbita-5,23(E)-dien...

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