Here, we report the draft genome of the filamentous cyanobacterium Desertifilum sp. strain IPPAS B-1220, isolated from Lake Shar-Nuur, Mongolia. The genome of 6.1 Mb codes for 5,113 genes. Genome mining revealed 10 clusters for the synthesis of bioactive compounds (nonribosomal peptides, polyketides, bacteriocins, and lantipeptides) with potential biotechnological or medical importance.

Background. Published research offers clear pointers to the management of heart failure; however, the evidence for implementation into practice is sub-optimal. Aim. To identify the salient barriers to adopting evidencebased management of heart failure in the community. Method. Structured interviews were used to elicit the views of a stratified sample of 100 general practitioners (GPs) about the...

353 Podiatric public health has been defined as that special area of podiatric medicine that is concerned with preventing, treating, and managing foot and related disorders and the pedal manifestations of systemic disease and promoting foot health through organized community efforts. In effect, it views the community as a whole, rather than the individual, as the “patient.” It focuses on educat...

We developed an algorithm, Lever, that systematically maps metazoan DNA regulatory motifs or motif combinations to sets of genes. Lever assesses whether the motifs are enriched in cis-regulatory modules (CRMs), predicted by our PhylCRM algorithm, in the noncoding sequences surrounding the genes. Lever analysis allows unbiased inference of functional annotations to regulatory motifs and candidat...

A hospital-based case-control study was conducted to evaluate the significance of methionine and folate related polymorphisms, with 72 colon and 70 rectal cancer cases and 241 non-cancer controls. The polymorphisms examined were in the genes for methionine synthase reductase (MTRR A66G), methionine synthase (MTR A2756G) and methylenetetrahydrofolate reductase (MTHFR C677T and A1298C). An uncond...

Cytochrome P450 enzymes from the CYP2C subfamily play a prominent role in the metabolic clearance of many drugs. CYP2C enzymes have also been implicated in the metabolism of arachidonic acid to vasoactive epoxyeicosatrienoic acids. CYP2C8, CYP2C9, and CYP2C19 are expressed in the adult liver at significant levels; however, the expression of CYP2C enzymes in extrahepatic tissues such as the brai...

Throughout the world, there are many threats to existing coral reefs. Global warming (1), mining (2), overfishing (3), and water pollution (4) all threaten the viability and health of coral reefs. Although these threats are well documented, programs to protect coral reefs are spotty and underfunded. Advocates for coral reef protection argue that there are many benefits to maintaining coral reef...

Agile microand nano-fluidic control is critical to numerous life science and chemical science synthesis as well as kinetic and thermodynamic studies. To this end, we have demonstrated the use of thin film transistor arrays as an active matrix addressing method to control an electrofluidic array. Because the active matrix method minimizes the number of control lines necessary (m + n lines for th...

Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require pharmacokinetic boosting. This work investigated the in vitro drug transport and metabolism of DTG and assessed the potential for clinical drug-drug interactions. DTG is a substrate for the efflux transporters P-glycoprotein (Pgp) and huma...