OBJECTIVES The purpose of this study was to assess the biodistribution and toxicity of amphotericin B (AMB) following multiple dose administration of an oral lipid-based formulation (iCo-009). METHODS BALB/c female mice were used. ICo-009 was administered twice daily for 5 days at doses of 2.5-20 mg/kg. Untreated animals, oral vehicle or intravenous Fungizone® (1 or 2 mg/kg) served as control...

PurposeCarpometacarpal (CMC) arthroplasty is an effective surgical treatment for osteoarthritis of the CMC joint. Risk factors readmission and reoperation have been studied other joint procedures but not yet arthroplasty. The purpose this study was to identify patient demographics comorbidities associated with 30-day after arthroplasty.MethodsThe American College Surgeons National Surgical Qual...

abstract a greenhouse experiment was conducted to study the effects of soil copper (cu) and salinity application on photosynthesis parameters, enzyme activity and anatomical structure of two pistachio cultivars. a factorial greenhouse experiment was carried out as completely randomized design with three replications. treatments consisted of four cu levels (0, 2.5, 5, and 7.5 mg kg-1soil as cuso...

the purpose of this study was to determine the effect of a session of endurance and sprint exercises on plasma anp in male athlete students. for this reason, 24 male athlete students were volunteered and randomized into endurance (n=8, age 24.5± 2.1 years, height 176.3± 3.5 cm, weight 71.75±4.6 kg), sprint (n=8, age 22.1±2.2 years, height 176.1±4.8 cm, weight 67.6±7.4 kg) and control groups (n=...

Chitosan treatment results in significantly lower serum LDL cholesterol 13 concentrations. To assess the working mechanism of chitosan, we measured serum surrogate 14 markers of cholesterol absorption (campesterol, sitosterol, cholestanol), synthesis (lathosterol, 15 lanosterol, desmosterol), and degradation to bile acids (7α-hydroxy-cholesterol, 27-hydroxy16 cholesterol) corrected for choleste...

BACKGROUND To investigate the effect of lisinopril on cardiac remodeling induced by smoking. MATERIAL/METHODS Rats were allocated into 3 groups: group CON (n=8): control; group CSE (n=8): cigarette smoke exposure; group CSE-LIS (n=8): exposed to tobacco smoke and treated with lisinopril. RESULTS After 2 months, the tail systolic pressure was lower in CSE-LIS (CON=116 +/-27 mm Hg, CSE=126+/-...

To determine how estrogens are involved in the growth of endometrial cancer with varying degrees of differentiation, we investigated the status of p72, a novel specific coactivator for estrogen receptor α (ERα) activation function-1 (AF-1), AIB1, a steroid receptor coactivator amplified in breast cancer 1, erbB-2, a receptor tyrosine kinase, and ERα in endometrial cancer. Gene expression of ERα...