نتایج جستجو برای: 3 gh

تعداد نتایج: 1820000  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شهید باهنر کرمان - دانشکده ریاضی و کامپیوتر 1391

در این پایان نامه به معرفی کلاسی از ابر ساختارها که gh- حلقه نامیده می شود خواهیم پرداخت. همچنین شرایط لازم و کافی برای اینکه gh- حلقه به gh- حلقه ی بخشی (و gh- حلقه بخشی قوی) تبدیل شود را بدست می آوریم. در ادامه مفهوم ایده آل ها در gh- حلقه و gh- حلقه با مجموعه ی همانی (به طور مختصر i- مجموعه) بیان شده است. قضیه یکریختی روی gh- حلقه ها که شبیه به قضیه ی اول یکریختی روی حلقه ها است را ثابت می ک...

Journal: :The Journal of clinical endocrinology and metabolism 2007
Vibor Petkovic Didier Lochmatter James Turton Peter E Clayton Peter J Trainer Mehul T Dattani Andrée Eblé Iain C Robinson Christa E Flück Primus E Mullis

CONTEXT AND OBJECTIVE Alteration of exon splice enhancers (ESE) may cause autosomal dominant GH deficiency (IGHD II). Disruption analysis of a (GAA) (n) ESE motif within exon 3 by introducing single-base mutations has shown that single nucleotide mutations within ESE1 affect pre-mRNA splicing. DESIGN, SETTING, AND PATIENTS Confirming the laboratory-derived data, a heterozygous splice enhancer...

Journal: :International journal of developmental research 2022

Introduction: The objective of this study was to evaluate the impact use anastrozole (ANZ) in monotherapy or associated with growth hormone (GH) predicted final height (PFH) and nearfinal (NFH) male adolescents PEF below target familiar (TH). Methods: This is a retrospective cohort. Data were obtained from medical records pediatric endocrinology service. Results: 75 patients between 11 14 years...

Journal: :American journal of physiology. Endocrinology and metabolism 2002
Craig A Jaffe D Kim Turgeon Kenneth Lown Roberta Demott-Friberg Paul B Watkins

The importance of gender-specific growth hormone (GH) secretion pattern in the regulation of growth and metabolism has been demonstrated clearly in rodents. We recently showed that GH secretion in humans is also sexually dimorphic. Whether GH secretion pattern regulates the metabolic effects of GH in humans is largely unknown. To address this question, we administered the same daily intravenous...

Journal: :Endocrinology 2001
S Jeay G E Sonenshein P A Kelly M C Postel-Vinay E Baixeras

Dependence of murine pro-B Ba/F3 cells on interleukin-3 can be substituted by GH when cells are stably transfected with the GH receptor (GHR) complementary DNA. Recently, we demonstrated that Ba/F3 cells produce GH, which is responsible for the survival of cells expressing the GHR. This GH effect involves the activation of nuclear factor-kappaB (NF-kappaB). Here, we examined the signaling pathw...

Journal: :Diabetes 2007
Juan-Pablo del Rincon Keiji Iida Bruce D Gaylinn Carrie E McCurdy J Wayne Leitner Linda A Barbour John J Kopchick Jacob E Friedman Boris Draznin Michael O Thorner

Phosphoinositide (PI) 3-kinase is involved in insulin-mediated effects on glucose uptake, lipid deposition, and adiponectin secretion from adipocytes. Genetic disruption of the p85alpha regulatory subunit of PI 3-kinase increases insulin sensitivity, whereas elevated p85alpha levels are associated with insulin resistance through PI 3-kinase-dependent and -independent mechanisms. Adipose tissue ...

Journal: :The Journal of biological chemistry 2001
G Piwien-Pilipuk D Van Mater S E Ross O A MacDougald J Schwartz

Growth hormone (GH) regulates transcription factors associated with c-fos, including C/EBPbeta. Two forms of C/EBPbeta, liver-activating protein (LAP) and liver inhibitory protein (LIP), are dephosphorylated in GH-treated 3T3-F442A fibroblasts. GH-induced dephosphorylation of LAP and LIP is reduced when cells are preincubated with phosphatidylinositol 3'-kinase (PI3K) inhibitors. GH activates A...

Journal: :Endocrinology 2003
Rocío Ajo Lucinda Cacicedo Constanza Navarro Franco Sánchez-Franco

To define the role of GH during central nervous system development, we performed studies in cultured rat cerebral cortical cells from 14- (E14) and 17-d-old embryos (E17). The expression of GH receptor, IGF-I receptor, and IGF-I mRNAs was confirmed. In E17, GH increased total cell number (3.9-fold), [(3)H]-thymidine incorporation (3.5-fold), proliferating cell nuclear antigen levels (2.5-fold),...

Journal: :American journal of medical genetics 1997
P D Ghidoni D E Hale J D Cody C T Gay N M Thompson E B McClure M M Danney R J Leach C I Kaye

The 18q- syndrome is one of the commonest deletion syndromes. Clinical characteristics are variable but may include: hypotonia, tapered digits, "carp-like" mouth, mental retardation, and hearing impairment. Growth failure (GF; both weight and height < 3%) was reported in 80% of affected individuals. We evaluated growth hormone (GH) sufficiency in 5 18q- syndrome patients, 3 of whom had growth f...

2016
Cheng-Zhi Wang Ling-Ling Guo Bai-Yu Han An-Ping Wang Hong-Yan Liu Xing Su Qing-Hua Guo Yi-Ming Mu

Objective. We aim to investigate the long-term benefits of growth hormone (GH) therapy in short stature adolescents and adults with pituitary stalk interruption syndrome (PSIS), which would be beneficial for future clinical applications. Design and Methods. In this study, initial height, final height, total height gain, and GH treatment history were retrospectively investigated in 75 Chinese PS...

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