The synthesis of 5' - deoxynucleoside 5' - phosphonates which contains a 5' - CP bond in place of the 5' -COP bond of the naturally occuring nucleotides is described. The preparation of phosphonate derivatives of acyclo - nucleosides and a simple method for the conversion of 1-? -D-ribofuranosyl pyrimidines to the corresponding 1-? -D-arabinofuranosyl pyrimidines are also explained

The Pd/C-CuI-PPh(3) catalytic system facilitated C-C bond formation between 4-chlorothieno[2,3-d]pyrimidines and terminal alkynes in methanol with high selectivity without generating any significant side products arising from C-O bond formation between the chloro compounds and methanol. A variety of novel 4-alkynylthieno[2,3- d]pyrimidines were prepared via alkynylation of 4-chlorothieno[2,3-d]...

Several novel naphtho[2,1-b]pyrano[2,3-d]pyrimidines, pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidines and their coumarin-3-yl derivatives were synthesized. Some of these derivatives exhibited pronounced antimicrobial activities.

the synthesis of 5' - deoxynucleoside 5' - phosphonates which contains a 5' - cp bond in place of the 5' -cop bond of the naturally occuring nucleotides is described. the preparation of phosphonate derivatives of acyclo - nucleosides and a simple method for the conversion of 1-? -d-ribofuranosyl pyrimidines to the corresponding 1-? -d-arabinofuranosyl pyrimidines are also ex...

Substituted pyrido[3,2-d]pyrimidines are accessible by a reaction sequence consisting of HWE-reaction, Z/E-photoisomerization, and ring closure the pyridine ring. Bis-pyridopyrimidines can be obtained from 7-amino-pyrido[3,2-d]pyrimidines.

A practical and new method for the synthesis oxindole substituted pyrrolo[2,3-d]pyrimidines by the condensation of isatin, acetophenone and 6-amino-uracil under ultrasound irradiation conditions at 60 °C was described. The reaction was developed via a sequential tandem process to afford the oxindole substituted pyrrolo[2,3-d]pyrimidines in good to excellent yields. All reactions performed effic...