نتایج جستجو برای: 3 cells

تعداد نتایج: 2968107  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تربیت مدرس - دانشکده پزشکی 1391

هدف: کشت سلول های اسپرماتوگونی و تولید سلول های پر توان embryonic stem cells (es like cells) که دارای قابلیت بازسازی و تولید هرسه نوع لایه زایای جنینی می باشند، این سلول ها را به عنوان منبع کافی و جدیدی برای سلول درمانی و ترمیم در بیماریها از جمله بیماریهای نورودژنراتیو پیشنهاد می دهد. در تحقیق حاضر تمایز سلول های اسپرماتوگونی موش به سلول های شبه الیگودندروسیت و نقش آنها درمیلین سازی پس از پیون...

پایان نامه :دانشگاه آزاد اسلامی - دانشگاه آزاد اسلامی واحد علوم دارویی - پژوهشکده علوم 1392

purpose a metabolic abnormality such as obesity is a major obstacle in the maintenance of the human health system and causes various chronic diseases including type 2 diabetes, hypertension, cardiovascular diseases, as well as various cancers. this study was designed to summarize the recent scientific knowledge regarding the anti-obesity role of curcumin (diferuloylmethane), which is isolated f...

Journal: :iranian journal of nuclear medicine 2011
seyed pezhman shirmardi mostafa erfani mohammad mazidi

introduction: bombesin is a 14-aminoacid peptide isolated from frog skin. the mammalian counterparts of the frog peptide are neuromedin b (nmb) and gastrin-releasing peptide (grp). bombesin (bbn) is a peptide showing high affinity for the gastrin releasing peptide receptor (grpr). prostate, small cell lung cancer, breast, gastric, and colon cancers are known to over express receptors to bombesi...

Journal: :iranian journal of pharmaceutical sciences 0
mona salimi pharmacology & physiology department, pasteur institute of iran, tehran, iran. parisa sarkhail pharmaceutical sciences research center, tehran univ. of medical sciences. tehran, iran. raheleh tahmasvand pharmacology & physiology department, pasteur institute of iran, tehran, iran maryam baeeri pharmaceutical sciences research center (psrc), tehran university of medical sciences, tehran, iran

the present study was designed to investigate the anti-melanogenic and cytotoxic activities of methanol extract of phlomis kurdica. the antioxidant and anti-tyrosinase activity of meoh extract from p. kurdica (mpk) were examined by dpph radical scavenging and mushroom tyrosinase activity assays (in vitro), respectively. furthermore, the effect of mpk on the melanin content, cellular tyrosinase ...

Roshangar L, Shafayi H Soleimani Rad J Valipour B,

Background: Omega-3 fatty acids can modify gene and protein expression through altering the function of transcription factors controlling gene expression. Cumulus expansion, is a critical process for normal oocyte development, ovulation, and fertilization. This event needs to the synthesis of hyaluronic acid and its production is controlled by the enzyme hyaluronic acid synthase 2 (HAS2). The a...

Journal: :iranian journal of pharmaceutical research 0
hassan malekinejad department of pharmacology and toxicology, faculty of veterinary medicine, urmia university, urmia, iran. masumeh moradi department of pharmacology and toxicology, faculty of veterinary medicine, urmia university, urmia, iran. johanna fink-gremmels department of veterinary, pharmacology, pharmacy and toxicology, faculty of veterinary medicine, utrecht university, yalelaan 104, 3508 td utrecht, the netherlands.

mycophenolic acid (mpa) is the active metabolite of mycophenolate mofetil. this study designed to investigate the mechanism of cytotoxicity of mpa on the genetically engineered pc12 tet off (pto) neuronal cells with p53 gene. alamar blue (ab) reduction showed concentration-dependent cytotoxicity of mpa on pto cells with ic50 value of 32.32 ± 4.61 mm. the reactive oxygen species (ros) generation...

ژورنال: Anatomical Sciences Journal 2012
Bakhtiyari, Mehrdad, Moghani Ghoroghi, Fatemeh, Nobakht, Maliheh, Esmaeilzade, Banfsheh, Hejazian , Leila Beygom,

Purpose: The aim of this study was to evaluate the effect of NT-3 on the decrease of the differentiation time of bulge stem cells of rat hair follicle from neuron like cells.Materials and Methods: The bulge region of the rat whisker was isolated from and cultured in DMEM/F12 supplemented with epidermal growth factor (EGF) in 3 groups for 7, 8 and 9 days .Then 10 ng/ml NT-3 was added to each gro...

CV KOOTEN, GR ASADI KARAM, GV ZANDBERGEN, MJ RASAEE, MR DAHA, SS ASGHAR,

Proteinase 3(PR3) is a human polymorphonuclear leukocyte serine proteinase and is the main target antigen for antineutrophil cytoplasmic antibodies (ANCA) found in Wegener's granulomatosis (WG). We developed a stable expression system for conformationally intact recombinant PR3 (rPR3) in Chinese hamster ovary cells (CHO-cells). The part of PR3 cDNA that encoded the active form of PR3 was s...

Journal: :veterinary research forum 2015
hassan malekinejad nazli alizadeh-tabrizi araz ostadi johanna fink-gremmels

the pathogenesis of equine grass sickness (egs) has not fully understood. a better understanding of the exact pathogenesis of diseases can help to make an accurate diagnosis. previous studies reported some pathological damage of neuronal cells in egs patients. in this study, primarily cytotoxicity of serum from three clinically egs-diagnosed horses on pc12 tet-off (pto) cells was assessed. subs...

Journal: :hepatitis monthly 0
kai li department of molecular biology on infectious disease, second affiliated hospital, chongqing medical university, chongqing, china shijia ding department of clinical laboratory diagnostics, chongqing medical university, chongqing, china ke chen department of molecular biology on infectious disease, second affiliated hospital, chongqing medical university, chongqing, china dongdong qin department of molecular biology on infectious disease, second affiliated hospital, chongqing medical university, chongqing, china jialin qu department of molecular biology on infectious disease, second affiliated hospital, chongqing medical university, chongqing, china sen wang department of molecular biology on infectious disease, second affiliated hospital, chongqing medical university, chongqing, china

background the hepatitis b virus x (hbx) protein has long been recognized as an important transcriptional transactivator of several genes. human aldo-keto reductase family 1, member c1 (akr1c1), a member of the family of akr1cs, is significantly increased in hbx-expressed cells. objectives this study aimed to investigate the possible mechanism of hbx in regulating akr1c1 expression in hepg2.2.1...

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