نتایج جستجو برای: 2dg electrophoresis

تعداد نتایج: 50889  

Journal: :iranian journal of cancer prevention 0
mehdi pooladi a) proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran b) dept. of biology, school of basic sciences, science and research branch, islamic azad university, tehran, iran mostafa rezaei-tavirani proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran mehrdad hashemi dept. of molecular genetics, tehran medical branch, islamic azad university tehran, iran saeed hesami-tackallou dept. of biology, garmsar branch, islamic azad university, garmsar, iran solmaz khaghani-razi-abad a) proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran b) dept. of biology, school of basic sciences, science and research branch, islamic azad university, tehran, iran afshin moradi dept. of pathology, shohada hospital, shahid beheshti university of medical sciences, tehran, iran

background : glioblastoma multiforme (gbm) or grade iv astrocytoma is the most common and lethal adult malignant brain tumor. several of the molecular alterations detected in gliomas may have diagnostic and/or prognostic implications, proteomics has been widely applied in various areas of science, ranging from the deciphering of molecular pathogen nests of discuses. method: we extracted protein...

Journal: :biomacromolecular journal 2015
mehdi pooladi

egfr is a key molecule in cancer cells. egfr signaling was shown to promote tumor cell proliferation and survival, invasion and angiogenesis and mediate resistance to treatment, including ionizing radiation in preclinical models. we extracted proteins from astrocytoma (iii and iv) oligodendroglioma(iv) tumors and normal brain tissues and then evaluated the protein purity by bradford test and sp...

Journal: :iranian journal of cancer prevention 0
mehdi pooladi 1. proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran 2. dept. of biology, school of basic sciences, science and research branch, islamic azad university, tehran, iran mostafa rezaei-tavirani proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran mehrdad hashemi dept. of molecular genetics, tehran medical branch, islamic azad university tehran, iran saeed hesami-tackallou dept. of biology, garmsar branch, islamic azad university, garmsar, iran solmaz khaghani-razi-abad 1. proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran 2. dept. of biology, school of basic sciences, science and research branch, islamic azad university, tehran, iran afshin moradi dept. of pathology, shohada hospital, shahid beheshti university of medical science, tehran, iran

background: dihydropyrimidinase related proteins (drps) have known homologous to the collapsing response mediator proteins (crmps). the drp gene family has comprised four members, drp 1, 2, 3, and 4, all out of which have considered to be involved in axonal outgrowth and path-finding. methods: the protein has extracted from tumor, normal brain tissues, and then the protein purity has evaluated ...

Journal: :Journal of animal science 1996
C R Krehbiel R A Britton D L Harmon J P Peters R A Stock H E Grotjan

Six crossbred steers (261 +/- 18 kg BW) fitted with hepatic portal, mesenteric venous and arterial catheters, and duodenal, midjejunal, and ileal cannulas were used in a replicated 3 x 3 Latin square design to determine the effect of varying levels and site of glucose plus 2-deoxyglucose (2DG) infusion on net portal-drained visceral flux. Steers were fed chopped alfalfa in six equal portions da...

Journal: :The Journal of General Physiology 1982
P Witkovsky C Y Yang

We studied the uptake of 2-deoxy-D-glucose (2DG) and the synthesis of its phosphorylated product 2DG-6-phosphate (2DG-6P) by the retinas of the clawed frog (Xenopus laevis) and the bullfrog (Rana catesbeiana). Autoradiographs showed that most of the retinal 2DG uptake is by the photoreceptor layer. The 2DG accumulation by isolated Xenopus retinas was time and concentration dependent. The Kt for...

2015
Thomas Mühlenberg Susanne Grunewald Jürgen Treckmann Lars Podleska Martin Schuler Jonathan A. Fletcher Sebastian Bauer

Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) is frequently used for visualizing gastrointestinal stromal tumors (GIST), which are highly glucose-avid tumors. Dramatic metabolic responses following imatinib treatment indicate a high, KIT-dependent glucose turnover which has been particularly helpful for predicting tumor response to imatinib. The glucose analogue 2-deoxygl...

Journal: :Molecular medicine reports 2009
Cholpon S Djuzenova Julia Krasnyanska Martin Kiesel Lavinia Stingl Ulrich Zimmermann Michael Flentje Vladimir L Sukhorukov

2-Deoxy-D-glucose (2DG), a well-known inhibitor of anaerobic glycolysis, is expected to exert cytotoxic and radiosensitizing effects. In order to test this hypothesis, the response of four tumor cell lines (U87-MG, GaMG, A549 and HT1080) to 2DG was analyzed for cell proliferation, changes in cell volume and nucleus size, as well as for radiation-induced DNA fragmentation, measured by the alkali...

Journal: :Molecular and cellular biology 2015
Allyson F O'Donnell Rhonda R McCartney Dakshayini G Chandrashekarappa Bob B Zhang Jeremy Thorner Martin C Schmidt

The glucose analog 2-deoxyglucose (2DG) inhibits the growth of Saccharomyces cerevisiae and human tumor cells, but its modes of action have not been fully elucidated. Yeast cells lacking Snf1 (AMP-activated protein kinase) are hypersensitive to 2DG. Overexpression of either of two low-affinity, high-capacity glucose transporters, Hxt1 and Hxt3, suppresses the 2DG hypersensitivity of snf1Δ cells...

Journal: :Experimental & molecular medicine 2010
Seon Mi Yu Hyun Ah Kim Song-Ja Kim

2-deoxy-D-glucose (2DG) is known as a synthetic inhibitor of glucose. 2DG regulates various cellular responses including proliferation, apoptosis and differentiation by regulation of glucose metabolism in cancer cells. However, the effects of 2DG in normal cells, including chondrocytes, are not clear yet. We examined the effects of 2DG on dedifferentiation with a focus on the beta-catenin pathw...

Journal: :Cancer research 2003
Xiao Lin Fanjie Zhang C Matthew Bradbury Aradhana Kaushal Ling Li Douglas R Spitz Rebecca L Aft David Gius

Exposure to ionizing radiation is believed to cause cell injury via the production of free radicals that are thought to induce oxidative damage. It has been proposed that exposure to agents that enhance oxidative stress-induced injury by disrupting thiol metabolism may sensitize cells to the cytotoxic effects of ionizing radiation. Recently, it has been shown that glucose deprivation selectivel...

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