The obesity epidemic and its associated morbidity and mortality have led to major research efforts to identify mechanisms that regulate appetite. Gut hormones have recently been found to be an important element in appetite regulation as a result of the signals from the periphery to the brain. Candidate hormones include ghrelin, peptide YY, glucagon-like peptide-1 and gastric inhibitory polypept...

Geopolitical competition between Russia and the US and EU on the periphery of the former USSR has complicated efforts to resolve lingering conflicts in Abkhazia, South Ossetia, Nagorno-Karabakh, and Transnistria. Regional and great power rivalries often obscure the distinctive local factors in each of these conflicts, which are ultimately crucial to their resolution. In addition, changes in loc...

We are witnessing a global financial and economic crisis, which may have far-reaching, and at least recently, unforeseeable consequences on the future and development of world science and technology. Control theory has always been an area of science driven by technology. From the statistical filtering solution formulated by R. Kalman in the early 1960s, devised for answering the needs of NASA's...

Clearly, the prevention and management of unintended pregnancy are primary health services needed by the majority of women of reproductive age, as well as many comparable men. The training that family physicians receive in family planning and first-trimester abortion is critical, yet few studies have investigated these aspects of their education. The Council on Residency Education in Family Pra...

The human mitochondrial cytochrome P450 enzymes CYP11A1, CYP11B1, and CYP11B2 are involved in the biosynthesis of steroid hormones.CYP11A1 catalyzes the side-chain cleavageof cholesterol, and CYP11B1 and CYP11B2 catalyze the final steps in the biosynthesis of glucoand mineralocorticoids, respectively. This study reveals their additional capability tometabolize the xenobiotic steroid oral turina...

rospectively. However, for years, retrospective reports of pregnancy wantedness have been recognized to be subject to recall error or rationalization. As long as three decades ago, it was noted that respondents might not admit to what could be perceived as an inadequacy, or that they might change their attitude based on positive experiences with a child resulting from a pregnancy that, at conce...

NATURE | VOL 410 | 8 MARCH 2001 | www.nature.com 227 12. DePace, A. H., Santoso, A., Hillner, P. & Weissman, J. S. A critical role for amino-terminal glutamine/ asparagine repeats in the formation and propagation of a yeast prion. Cell 93, 1241–1252 (1998). 13. Patino, M. M., Liu, J. J., Glover, J. R. & Lindquist, S. Support for the prion hypothesis for inheritance of a phenotypic trait in yeas...

Advanced single-cell analysis technologies (e.g., mass cytometry) that help in multiplexing cellular measurements in limited-volume primary samples are critical in bridging discovery efforts to successful drug approval. Mass cytometry is the state-of-the-art technology in multiparametric single-cell analysis. Mass cytometers (also known as cytometry by time-of-flight or CyTOF) combine the cellu...