1 Abstract Since the industrial revolution, standardization has become a hybrid of technical design and political processes with major impact on markets, social welfare and economic activity. Standards are increasingly developed outside government regulatory venues in consortia and other forms of voluntary consensus bodies involving collaboration among private sector competitors, suppliers, cus...

been rising, it represents only 20% of method use among 15–44-year-old women.7 In addition, the widespread availability of modern, efficient contraceptives—sterilization, the pill, IUD, implant and injectable—contributes to low rates of condom use. However, while these methods are more effective than barrier methods at preventing pregnancy, do not reduce sensitivity or pleasure during intercour...

Navitoclax (ABT-263), a Bcl-2 family inhibitor and ABT-199, a Bcl-2 selective inhibitor, are high molecular weight, high logP molecules that show low solubility in aqueous media. While these properties are associated with low oral bioavailability (F), both navitoclax and ABT-199 showed moderate F in preclinical species. The objective of the described study was to determine if lymphatic transpor...

ion at the b-C. Relative yields are changed as much as a factor of 7.0 at 200 K, a factor of 5.0 at 298 K, and a factor of 3.7 in the other direction at 2400 K. The strong dependence of the product ratios on the multi-structural anharmonicity factors shows that such factors play an important role in controlling branching ratios in reaction mechanism networks.

Estrogen is a hormone critical in the development, normal physiology and pathophysiology1 of numerous human tissues2. The effects of estrogen have traditionally been solely ascribed to estrogen receptor a (ERa) and more recently ERb, members of the soluble, nuclear ligand–activated family of transcription factors3. We have recently shown that the seventransmembrane G protein–coupled receptor GP...

Concerns exist about adequacy of vitamin D in pregnant women relative to both maternal and fetal adverse health outcomes. Further contributing to these concerns is the prevalence of inadequate and deficient vitamin D status in pregnant women, which ranges from 5 to 84% globally. Although maternal vitamin D metabolism changes during pregnancy, the mechanisms underlying these changes and the role...

Introduction Let C be a convex bounded body in the n-dimensional Euclidean space E, and let B be its boundary. We use Busemann's notations: E(a,b) for the segment {(1 — p)a + pb: 0 < p ^ 1} from a to b, and S(z, p) for the sphere {x: \\z — x\\ = p). We now recall the definition of Hammer's associated bodies C(r). Let Cb(r) be the set obtained from C by a similitude transformation with a ratio r...