نتایج جستجو برای: 21 cell
تعداد نتایج: 1893331 فیلتر نتایج به سال:
in this study, the immunogenicity of a rabies vaccine that was used in one of the isfahan cattle farms is reported. this vaccine was produced by replication of the pasteur virus (pv) strain on bhk-21 monolayer cell culture. the virus suspension was inactivated by ß-propiolactone treatment and the harvested pool showed sterility and safety. thus, the obtained vaccine was tested on mice and a sat...
compared to other methods of vaccine production, (e.g. culture flask and bioreactor system), the roller culture method for producing rabies vaccine is simpler, and the equipment easier to install and maintain, and also in the event of contamination of one roller, the entire batch need not be discarded. this system provides a much larger surface area than the culture flask, and also ensures a mu...
تحقیقات مختلف اثبات نموده اند که رشد و محتوای بیوشیمیایی روتیفرها می تواند تحت تاثیر نوع غذا و غلظت مواد غذایی تغییر نماید. ریز جلبک ها به عنوان یکی از منابع غذایی مهم برای کشت روتیفرها به ویژه از لحاظ شاخص های نظیر رشد، بقا، میزان پروتئین، چربی و اسیدهای چرب، ضروری می باشند. لذا تحقیق حاضر جهت مقایسه جلبک خشک (کلرلای پودری) و جلبک های تازه (ایزوکرایسیس گالبانا و نانوکلروپسیس آکولاتا) بر رشد، ت...
down syndrome (ds) is a birth defect with huge medical and social costs, caused by trisomy of whole or part of chromosome 21. it is the most prevalent genetic disease worldwide and the common genetic cause of intellectual disabilities appearing in about 1 in 400-1500 newborns. although the syndrome had been described thousands of years before, it was named after john langdon down who described ...
IL-21 has been shown to play an important role in the CD8 T cell response during acute and chronic viral infections. However, the role of IL-21 signaling in the CD4 T cell response to viral infection remains incompletely defined. In a model of infection with vaccinia virus, we show that intrinsic IL-21 signaling on CD4 T cells was critical for the formation of memory CD4 T cells in vivo. We fur...
IL-21 plays a key role in the late stage of B cell development, where it has been shown to induce growth and differentiation of mature B cells into Ig-secreting plasma cells. Because IL-21R has also been reported on bone marrow (BM) B cell progenitors, we investigated whether IL-21R influenced earlier stages of B cell development. IL-21R is functional as early as the pro-B cell stage, and the s...
Abstract MicroRNA-21 (miR-21) is upregulated in SLE patients and promotes disease multiple autoimmune mouse models; however, mechanisms by which miR-21 promote autoimmunity are unknown. Here we show that TLR7 overexpressing SLE-prone B6.Sle1b Yaamice deficient (Sle1b YaamiR-21 −/−) resisted development through reduced germinal center (GC) B cell, T follicular helper plasma cell responses. Sle1b...
T follicular regulatory (Tfr) cells control the magnitude and specificity of the germinal centre reaction, but how regulation is contained to ensure generation of high-affinity antibody is unknown. Here we show that this balance is maintained by the reciprocal influence of interleukin (IL)-2 and IL-21. The number of IL-2-dependent FoxP3+ regulatory T cells is increased in the peripheral blood o...
Chronic viral infection is often associated with the dysfunction of virus-specific T cells. Our studies using Il21r-deficient (Il21r-/-) mice now suggest that interleukin-21 (IL-21) is critical for the long-term maintenance and functionality of CD8+ T cells and the control of chronic lymphocytic choriomeningitis virus infection in mice. Cell-autonomous IL-21 receptor (IL-21R)-dependent signalin...
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