background the hepatitis b virus x (hbx) protein has long been recognized as an important transcriptional transactivator of several genes. human aldo-keto reductase family 1, member c1 (akr1c1), a member of the family of akr1cs, is significantly increased in hbx-expressed cells. objectives this study aimed to investigate the possible mechanism of hbx in regulating akr1c1 expression in hepg2.2.1...

the aggregation of protein is the most prevalent and the most disturbing kind of instability and this challenge exists in almost every stage of the development of protein drug. the presence of insoluble aggregations in protein drugs will make the supply of the product a tough job. this study identifies the inhibition of the folded interferon beta 1-b’s aggregation with the assistance of some ex...

It has recently been found (Bekisz and Wróbel 1993) that electroencephalographic recordings from the primary visual cortex and lateral geniculate nucleus of cats attending to visual stimuli contained enhanced activity in the 20 Hz frequency band. Here we present the detailed analysis of this activity. It consisted of short (0.1-1 s) bursts of oscillations which tended to appear simultaneously i...

Homologation of 16-dehydropregnenolone acetate leads to excellent stereocontrolled synthesis of unnatural C (20R) aldehydes and through compound .