the anti-apoptotic gene bcl-2 is located in mitochondria, but it is uncertain whether its expression affects hepatocyte survival in ischemia/reperfusion (i/r) injury. this experiment was designed to evaluate the role of folic acid in expression of bcl-2 in i/r in rat liver. eighteen wister rats were divided into sham-operated controlgroup (c) (n=6), i/r group (n=6), folic acid treated group whi...

background: radiation therapy is among the most conventional cancer therapeutic modalities with effective local tumor control. however, due to the development of radio-resistance, tumor recurrence and metastasis often occur following radiation therapy. in recent years, combination of radiotherapy and gene therapy has been suggested to overcome this problem. the aim of the current study was to e...

objective: the incidence of breast cancer is approximately one million which makes this cancer one of the most common among women worldwide. breast cancer comprises 7% of the total death rate caused by cancers. several strategies that use tumor-associated antigen (taa) vaccination and early detection of breast cancer are clinically being developed. breast cancer is caused by increased over expr...

the mucus layer plays an important role as an intermediate for the protection of the gut against acidic chyme, digestive enzymes, and pathogens; in addition, it acts as a lubricant and facilitator of nutrient transportation. phytogenic compounds seem to promote intestinal mucus production. objectives: the current study was conducted to investigate the effects of low and high levels of energy an...

despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. recently, human cytomegalovirus (hcmv) was reported as a risk factor for breast cancer. the aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? in this experiment seventeen samples of razi/a mice with spontaneous breast cancer were being gathered fr...

conclusions it can be concluded that the nettle extract can reduce blood glucose levels in diabetic mice, at least partly, by influencing the glut2 gene expression in mice liver. results the results showed that the nettle extract significantly decreased high levels of blood glucose (p < 0.001). the nettle extract also had a preventive effect on decrease in body weight. in addition, the results ...

there are much heterogeneity in the genetic variation of type 2 diabetes (t2d). the purpose of this study was to investigate the association of seven novel genetic loci identified in a recent genome-wide association studies (gwas) with t2d in chinese dong populations.a case-controlled study was performed in individuals of chinese dong nationality. the genotypes of pard3b (rs849230), loc729993 (...

b a ckground: the objective was to investigate the relationship between serum interleukin-18 (il-18), pentraxin 3 (ptx3), and high-sensitivity c-reactive protein (hs-crp) levels with body mass index (bmi) and abdominal obesity and also the interaction between genetic variants of apolipoprotein a-ii (apo a-ii) and obesity on the levels of these factors in type 2 diabetes patients (t2d). m ethods...