INTRODUCTION Currently available endothelin receptor antagonists for treating pulmonary arterial hypertension block either the endothelin (ET) receptor A or both A and B receptors. Transition from one endothelin receptor antagonist to another may theoretically alter side-effects or efficacy. We report our experience of a transition from sitaxsentan to ambrisentan, both predominant ET(A) recepto...

Sorption of four herbicides and a metabolite of indaziflam on a fresh macadamia nut biochar and biochars aged one or two years in soil was characterized. On fresh biochar, the sorption was terbuthylazine (Kd = 595) > indaziflam (Kd = 162) > MCPA (Kd = 7.5) > fluoroethyldiaminotriazine (Kd = 0.26) and nicosulfuron (Kd = 0). Biochar surface area increased with aging attributed to the loss of a su...

This paper presents the constraints on the time variation of the fine structure constant at recombination relative to its present value, ∆α = (αrec − α0)/α0, obtained from the analysis of the WMAP-3yr Cosmic Microwave Background (CMB) data, with an additional prior on the Hubble expansion rate from HST Hubble Key Project. I found out that −0.039 < ∆α < 0.010 at 95% C.L., which brings a 30% impr...

In clinical practice, it is important to predict as soon as possible after diagnosis and starting treatment, which children are destined to develop medically intractable seizures and be at risk of increased mortality. In this study, we determined factors predictive of long-term seizure and mortality outcome in a population-based cohort of 102 children. At the end of the 40-year median follow-up...

This study evaluated the effect of 24 h (1d) and one-year (1yr) water storage on the microtensile dentin bond strength of a two-step total-etch and a two-step self-etch adhesive system. Ten extracted human third molars were sectioned perpendicularly to their long axis to expose flat occlusal dentin surfaces. Teeth were divided into two groups (n=5) according to the adhesive used: a two-step etc...

Interannual variations in CO2 exchange across Amazonia, as deduced from atmospheric inversions, correlate with El Niño occurrence. They are thought to result from changes in net ecosystem exchange and fire incidence that are both related to drought intensity. Alterations to net ecosystem production (NEP) are caused by changes in gross primary production (GPP) and ecosystem respiration (Reco). H...

Background and Purpose: Resting functional MRI was utilized to depict brain regions exhibiting temporal synchronization, also known as resting brain functional connectivity (rfc). This study aims to determine the temporal and spatial patterns of rfc in healthy pediatric subjects between 2wks and 2yrs old. Methods: Rfc studies were performed on 85 children: 38 neonates (2-4 wks), 26 1yr olds and...

Conventional wisdom postulates that leaching losses of N from agriculture systems are dominated by NO3 – . Although the export of dissolved organic nitrogen (DON) into the groundwater has been recognized for more than 100 yr, it is often ignored when total N budgets are constructed. Leaching of DON into stream and drinking water reservoirs leads to eutrophication and acidifi cation, and can pos...