Emerging evidence indicates that the aryl hydrocarbon receptor (AhR) plays a crucial role in normal physiologic homeostasis. Additionally, aberrant AhR signaling leads to several pathologic states in the lung and liver. Activation of AhR transcriptionally induces phase I (CYP1A) detoxifying enzymes. Although the effects of the classic AhR ligands such as 3-methylcholanthrene and dioxins on phas...

This study aimed to investigate the impact of methylxanthine abstinence (MA) periods on CYP1A2 activity in individuals with varying levels of caffeine consumption through development of a population pharmacokinetic model of caffeine and its major metabolite paraxanthine. This study developed and evaluated a mixed-effects pharmacokinetic model for caffeine and paraxanthine concentration-time dat...

Emerging evidence indicates that the aryl hydrocarbon receptor (AhR) plays a crucial role in normal physiologic homeostasis. Additionally, aberrant AhR signaling leads to several pathologic states in the lung and liver. Activation of AhR transcriptionally induces phase I (CYP1A) detoxifying enzymes. Although the effects of the classic AhR ligands such as 3-methylcholanthrene and dioxins on phas...

(i) Westminster Hospital, 1716-1966, by J. G. HUMBLE AND P. HANSELL, London, Pitman Medical Publishing Co., 1966, pp. x, 134, illus., 21s. (ii) Geschichte des Hospitals, Bd. 1: Westdeutschland von den Anfdngen bis 1850, by D. JETFER (Sudhoffs Archiv, Beiheft 5), Wiesbaden, Franz Steiner Verlag, 1966, pp. viii, 270, 104 illus., DM. 66 or 74. These two books could hardly be more different. Dr. Hu...

Emerging evidence indicates that the aryl hydrocarbon receptor (AhR) plays a crucial role in normal physiologic homeostasis. Additionally, aberrant AhR signaling leads to several pathologic states in the lung and liver. Activation of AhR transcriptionally induces phase I (CYP1A) detoxifying enzymes. Although the effects of the classic AhR ligands such as 3-methylcholanthrene and dioxins on phas...

Emerging evidence indicates that the aryl hydrocarbon receptor (AhR) plays a crucial role in normal physiologic homeostasis. Additionally, aberrant AhR signaling leads to several pathologic states in the lung and liver. Activation of AhR transcriptionally induces phase I (CYP1A) detoxifying enzymes. Although the effects of the classic AhR ligands such as 3-methylcholanthrene and dioxins on phas...

The space-charge limit on the beam current which can be usefully stored in a colliding-beam storage ring is determined by the current density in the interaction region and, in the case of a thin, flat ribbon beam, by the value of PY., the vertical P-function there. The quantity which is limited is the dimensionless parameter , JP r 2 6 a constant Y where J is the current density in the interact...