Corticocortical interactions between the primary motor cortex, the ventral premotor cortex and posterior parietal motor areas, such as the anterior and caudal intraparietal sulcus, are relevant for skilled voluntary hand function. It remains unclear to what extent these brain regions and their interactions also contribute to basic motor functions after stroke. We hypothesized that white matter ...

Craig C. Mello is an American developmental biologist and Nobel Laureate, who helped discover RNA interference [4] (RNAi). Along with his colleague Andrew Fire [5], he developed gene knockouts using RNAi. In 2006 Mello won the Nobel Prize in Physiology or Medicine [6] for his contribution to the discovery of RNAi. Mello also contributed to developmental biology, focusing on gene regulation [7],...

Vasa is a conserved RNA-helicase found in the germ lines of all metazoans tested. Whereas Vasa presence is often indicated as a metric for germline determination in animals, it is also expressed in stem cells of diverse origin. Recent research suggests, however, that Vasa has a much broader function, including a significant role in cell cycle regulation. Results herein indicate that Vasa is uti...

Apical and basolateral determinants specify and maintain membrane domains in epithelia. Here, we identify new roles for two apical surface proteins – Cadherin 99C (Cad99C) and Stranded at Second (SAS) – in conferring apical character in Drosophila tubular epithelia. Cad99C, the Drosophila ortholog of human Usher protocadherin PCDH15, is expressed in several embryonic tubular epithelial structur...

A Midsummer Reminiscence In June of 1957 word came to me in Zurich that Dr. Fulton was gravely ill. He had recently arrived in London to celebrate the Harvey Tercen-tenary and was to go on from there to Oxford to receive an honorary degree. He had rallied from critical illnesses before, but this time it seemed that the end had come. I boarded a plane for London. The muffled roar of the all-but-...

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This paper celebrates a 25th birthday, a record of learning and teaching across the Commonwealth. It began in 1959, when Philip Evans (secretary, British Paediatric Association 1954-59) and Reginald Lightwood (Head of University Department of Paediatrics, St Mary's Medical School, London), convinced that paediatric teaching exchanges would improve child health within the Commonwealth, sought th...