Motivation: Many methods predict the physical interaction between two proteins (protein-protein interactions; PPIs) from sequence alone. Their performance drops substantially for proteins not used for training. Results: Here, we introduce a new approach to predict PPIs from sequence alone which is based on evolutionary profiles and profile-kernel support vector machines. It improved over the st...

Jane Maienschein is the daughter of Joyce Kylander [5] and Fred Maienschein [6], and was born in Oak Ridge, Tennessee, on 23 September 1950. She attended MIT as a freshman and then transferred to Yale University [7] in 1969 when Yale decided to admit women undergraduates. In 1972 she graduated with an honors degree in History, the Arts, and Letters having written a thesis on the history of scie...

ONE of the duties incumbent upon an international scientific organization is the establishment of a system of standard measures and methods for general use within its particular science. In ophthalmology, this need was beginning to be felt at the end of the 19th century, and at the X Ophthalmological Congress which was held at Lucerne in 1904 the Societe franQaise d'Ophtalmologie made certain p...

Apical and basolateral determinants specify and maintain membrane domains in epithelia. Here, we identify new roles for two apical surface proteins – Cadherin 99C (Cad99C) and Stranded at Second (SAS) – in conferring apical character in Drosophila tubular epithelia. Cad99C, the Drosophila ortholog of human Usher protocadherin PCDH15, is expressed in several embryonic tubular epithelial structur...

Successive reports* in this Journal on the progress of poliomyelitis in the Bristol area serve to co-relate the disease with other infections but reduce what can be usefully said that is new about this much publicised disease. Therefore, it seems best to place before you the bare bones of the incidence during 1950, as reflected in admissions recorded at Ham Green Hospital, and thereafter commen...