In this study, we investigate the relationship between uncertainty and trust in exogenous shifts in modes of social exchange (i.e., those that are not initiated by the individuals in a given exchange system). We explore how transitions from a high uncertainty environment (reciprocal exchange) to lower-uncertainty environments (nonbinding or binding negotiated exchange) affect the level of trust...

As oestrogen deficiency is the main cause in the pathogenesis of osteoporosis hormonereplacement therapy remains the mainstay for prevention. However, prophylaxis by hormonereplacement therapy is limited. Phyto-oestrogens, which are weakly-oestrogenic compounds present in plants, deserve particular mention because emerging data support the suggestion that they may prevent bone loss associated w...

We describe an unusual case of acute promyelocytic leukemia with +der(17)t(15;17) as the additional cytogenetic abnormality and with t(15;17) defined by fluorescence in situ hybridization (FISH) using a PML/RARA dual color, dual fusion translocation probe. By performing a step-by-step, complementary approach to evaluate unusual chromosomal abnormalities, we detected RARA/PML fusion on a marker ...

Hubble Space Telescope images of the core-collapse supernova remnant Cassiopeia A are used to identify highvelocity knots of ejecta located outside the remnant’s main emission shell of expanding debris. These ejecta fragments are found near or ahead of the remnant’s forward shock front and mostly lie from 12000 to 30000 in radial distance from the remnant’s center of expansion. Filter flux rati...

Although many components of the genetic pathways that provide positional information during embryogenesis have been identified, it remains unclear how these signals are integrated to specify discrete tissue territories. Here, we investigate the molecular mechanisms underlying the formation of one of the hindbrain segments, rhombomere (r) 3, specified by the expression of the gene krox20. Dissec...

BACKGROUND AND AIM Aberrant activation of the TGF-β1/Smad pathway contributes to the activation of hepatic stellate cells (HSCs). MicroRNA-195 has been shown to regulate the activation of HSCs. The aim of this study was to investigate the role of miRNA-195 in HSCs activation. METHODS A liver fibrotic rat model induced by diethylnitrosamine was established. Dual luciferase reporter assays were...