Acreative intellect, he contributed profoundly to our understanding of the molecular biology of development. From his early work on the structure of the eucaryotic chromosome to the recent identification of genes capable of etic-iting an entire program of cellular differentiation, Hal repeatedly identified important problems in biology and solved them in an elegant fashion. For those fortunate ...

Drug treatment of neonates and infants and its long-term consequences on drug responses have emerged in recent years as amajor challenge for health care professionals. In the current study, we use phenobarbital as a model drug and mouse as an in vivo model to demonstrate that the dose of phenobarbital and age of treatment are two key factors for the persistent induction of gene expression and c...

should be subjected to constant changes of nomenclature crops up at regular intervals. The only criticism is a personal one. The English throughout the book is of the Shakespearean type, at times so precise and at others so flowery as to be pedantic. For instance, page 114, describing one of the approaches to the popliteal fossa: "A plan intending to exploit the rear of any situation solely fro...

Motivation: Haplotypes play a crucial role in genetic analysis and have many applications such as gene disease diagnoses, association studies, ancestry inference and so forth. The development of DNA sequencing technologies makes it possible to obtain haplotypes from a set of aligned reads originated from both copies of a chromosome of a single individual. This approach is often known as haploty...

We are met here to-day in thankful remembrance of the life and work of Thomas Barlow. A memorial service has already been held for him elsewhere which was largely attended by his many friends both lay and medical, but it is fitting that we should have our own simple service here in the Hospital to which he was so much devoted and where much of his best work was done. We may look upon it, I thin...

14 species of the Siobla formosana species-group are revised. Three new species: Siobla jiangi Niu & Wei, sp. nov., S. parallela Niu & Wei, sp. nov., S. weiweii Niu & Wei, sp. nov. are described. Siobla rufipes Malaise, 1945 is a new synonym of S. atra Malaise, 1945. The males formerly assigned to S. atra belong to S. semipicta Malaise, 1945. The previously unknown female of Siobla rufopropodea...

Ruxandra Sireteanu, a leading researcher in experimental and clinical visual neuroscience, died on September 1, 2008 in Frankfurt am Main, Germany. At the height of her academic and scientific career, shortly before her 63rd birthday, she unexpectedly passed away following brain trauma. Ruxandra Sireteanu is best known in the scientific community for her pioneering work on neural plasticity and...

Motivation: Many methods predict the physical interaction between two proteins (protein-protein interactions; PPIs) from sequence alone. Their performance drops substantially for proteins not used for training. Results: Here, we introduce a new approach to predict PPIs from sequence alone which is based on evolutionary profiles and profile-kernel support vector machines. It improved over the st...

Springer-Verlag: History ofa scientific publishing house, Heinz Sarkowski, Part 1, 1842-1945: Foundation, maturation, adversity, 1842-1945, transl. Gerald Graham; Heinz Gotze, Part 2, 1945-1992: Rebuilding, opening frontiers, securing the future, transl. Mary Schafer, Berlin and Heidelberg, SpringerVerlag, 1996, pt 1, pp. xviii, 448, illus.; pt 2, pp. xxvi, 416, illus., £58.00, DM 124.00 (3-540...