Tissue factor (TF) is expressed strongly in various types of cancer, especially cancers that are often refractory to treatment, such as pancreatic cancer. In this study, we compared the differences in the biophysical and pharmacological properties of whole IgG and the Fab fragment of anti-human TF monoclonal antibody (1849 antibodies), in order to determine their suitability for application in ...

The species-group name Pagurus longitarsus was proposed by De Haan (1849: 211, pl. 50, fig. 3) for a species of hermit crab collected from Japan (see Yamaguchi & Baba 1993: 272, 273). Dana (1852b: 464) transferred Pagurus longitarsus to the genus Clibanarius Dana, 1852 (first established in Dana 1852a). Dana (1852b: 464) also suggested that Pagurus longitarsus De Haan, 1849, and Pagurus asper H...

We designate lectotypes and propose nomenclatural changes in Xylographus Mellié (Coleoptera, Ciidae) based on type specimens deposited in the Museum of Comparative Zoology (USA), Museum für Naturkunde Berlin (Germany), the Natural History Museum (UK), Muséum d'Histoire Naturelle de la Ville de Genève (Switzerland), Muséum National d'Histoire Naturelle (France), Naturhistoriska Riksmuseet (Swede...

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Homeoproteins of the Engrailed family are involved in the patterning of mesencephalic boundaries through a mechanism classically ascribed to their transcriptional functions. In light of recent reports on the paracrine activity of homeoproteins, including Engrailed, we asked whether Engrailed intercellular transfer was also involved in brain patterning and boundary formation. Using time-controll...

Vesico-vaginal fistula (VVF) was a common ailment among American women in the 19th century. Prior to that time, no successful surgery had been developed for the cure of this condition until Dr J Marion Sims perfected a successful surgical technique in 1849. Dr Sims used female slaves as research subjects over a four-year period of experimentation (1845-1849). This paper discusses the controvers...

BACKGROUND The Ukrainian Anomaloninae fauna is relatively poorly known. The presence of large under-collected areas, such as the Carpathians, makes taxonomic and faunistic studies concerning these parasitoids from Ukraine urgently relevant. NEW INFORMATION Based on our ongoing surveys on the Anomaloninae of the Ukrainian Carpathians, we report here the new distribution records for some specie...

UNLABELLED The type status is described of 404 taxa classified within the family Bulimulidae (superfamily Orthalicoidea) and kept in the London museum. Lectotypes are designated for Bulimus aurifluus Pfeiffer, 1857; Otostomus bartletti H. Adams, 1867; Helix cactorum d'Orbigny, 1835; Bulimus caliginosus Reeve, 1849; Bulimus chemnitzioides Forbes, 1850; Bulimus cinereus Reeve, 1849; Helix cora d'...

Our mouth waters when we think of our favourite food, and so does that of a dog. But can we know what a dog is thinking about? An experimental entry to a dog's mind was achieved by Pavlov through a rather convoluted chain of studies performed at the beginning of the century that is now coming to an end. His approach is now common knowledge. If presentation of food is preceded every time by a be...