941-Pos Optimizing Super Resolution Microscopy Kim I. Mortensen1, L. Stirling Churchman2, James A. Spudich2, Henrik Flyvbjerg1. Technical University of Denmark, Kongens Lyngby, Denmark, Stanford University School of Medicine, Stanford, CA, USA. Super-resolution microscopy is often done by imaging isolated fluorescent probes as diffraction-limited spots with objective-type total internal fluores...

Organic cation transporters (OCTs) are members of the solute carrier 22 family of transporter proteins that are involved in absorption, distribution, and excretion of organic cations. OCT3 is localized in the apical (AP) membrane of enterocytes, but the literature is ambiguous about OCT1 (mOct1) localization, with some evidence suggesting a basolateral (BL) localization in human and mouse enter...

Since low birth weight is a leading cause of infant mortality,7 varying rates of this outcome among Hispanic subgroups may translate to similarly varying patterns in infant mortality. On the other hand, if access to neonatal intensive care services differs by maternal birthplace or ethnicity, then infant mortality rates might not reflect differences in low-birth-weight rates among Hispanic subg...

Loss of chromosome 1p/19q in oligodendrogliomas represents a powerful predictor of good prognosis. Expression of internexin (INA), a neuronal specific intermediate filament protein, has recently been proposed as a surrogate marker for 1p/19q deletion based on the high degree of correlation between both parameters in oligodendrogliomas. The aim of this study was to assess further the diagnostic ...

Evaluation of drug-drug interaction (DDI) involving circulating inhibitory metabolites of perpetrator drugs has recently drawn more attention from regulatory agencies and pharmaceutical companies. Here, using amiodarone (AMIO) as an example, we demonstrate the use of physiologically based pharmacokinetic (PBPK) modeling to assess how a potential inhibitory metabolite can contribute to clinicall...

mother and her offspring include high rates of school dropout, low-birth-weight infants, poor health and poverty.4 In addition, teenage childbearing results in considerable financial costs to taxpayers and society.5 A significant amount of attention and energy has been devoted to the prevention of teenage pregnancy through, for example, school-based programs to increase condom use, sexuality ed...

Although organic anion transporting polypeptide (OATP)–mediated hepatic uptake is generally conserved between rodents and humans at a gross pharmacokinetic level, the presence of three major hepatic OATPs with broad overlap in substrate and inhibitor affinity, and absence of rodent-human orthologs preclude clinical translation of single-gene knockout/knockin findings. At present, changes in pha...

In sub-Saharan Africa almost all of the malaria deaths occur in children below five years of age and these deaths occur within 48 hours of onset of symptoms. Consequently, the home management of malaria (HMM), was introduced to ensure early recognition of and prompt and appropriate response to malarial illness in children within the home or the community. In this report the impact of HMM in chi...