A new synthetic method for chiral oxazolidinone derivatives, therapeutic agents for treating urinary disturbance, is described. The condensed compound obtained from chiral 1-amino-3-phenyl-2-propanol and 1-phenyl-3-morpholino-1-propanone was reduced with Me4NBH(OAc)3 to give the intermediate, 1-(3-morpholino-1-phenylpropyl)amino-3-phenyl-2-propanol (MAPP) in 34% diastereomeric excess (d.e.). MA...

The basal ganglia control body movements, value processing and decision-making. Many studies have shown that the inputs and outputs of each basal ganglia structure are topographically organized, which suggests that the basal ganglia consist of separate circuits that serve distinct functions. A notable example is the circuits that originate from the rostral (head) and caudal (tail) regions of th...

In England in 1800 a profound change occurred that ushered in an important component in the regime of modern economic growth. In pre-industrial England, from 1250 to 1800, the rich produced many more surviving children than the poor. From 1800 to 1875 there was no association between wealth and net fertility. And after 1875 wealth became strongly negatively associated with net fertility. Why th...

In England in 1800 a profound change occurred that ushered in an important component in the regime of modern economic growth. In pre-industrial England, from 1250 to 1800, the rich produced many more surviving children than the poor. From 1800 to 1875 there was no association between wealth and net fertility. And after 1875 wealth became strongly negatively associated with net fertility. Why th...

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<5E−38 45–102 1 206 e+ e− 1 ABBIENDI 08 OPAL <0.2E−36 200–700 1 1960 pp 2 ABULENCIA 06K CNTR < 2.E−36 1 300 e+ p 3,4 AKTAS 05A INDU < 0.2 E−36 2 300 e+ p 3,4 AKTAS 05A INDU < 0.09E−36 3 300 e+ p 3,4 AKTAS 05A INDU < 0.05E−36 ≥ 6 300 e+ p 3,4 AKTAS 05A INDU < 2.E−36 1 300 e+ p 3,5 AKTAS 05A INDU < 0.2E−36 2 300 e+ p 3,5 AKTAS 05A INDU < 0.07E−36 3 300 e+ p 3,5 AKTAS 05A INDU < 0.06E−36 ≥ 6 300 e...

Tim topics chosen by former Monckton Copeman lecturers on the relations between the City of London and Medicine have been wide and varied. The present subject is the apothecaries who came to this country and especially to London, many of them as refugees, during the seventeenth and eighteenth centuries, and their place in pharmacy. Long before the massacre of St. Bartholomew in 1572, refugees f...

Using ambulatory ph-metry, intragastric acidity was measured over three separate 24 hour periods in each of 12 healthy volunteers receiving either (a) placebo (1800 h and 2200 h), (b) 300 mg ranitidine (1800 h) and placebo (2200 h), or (c) placebo (1800 h) and 300 mg ranitidine (2200 h). Ranitidine was significantly more effective in decreasing 24 h median intragastric acidity when the drug was...