Interleukin 17B (IL-17B) is a pro-inflammatory cytokine that belongs to the IL-17 cytokines family and binds to IL-17 receptor B (IL-17RB). Here we found that high expression of IL-17B and IL-17RB is associated with poor prognosis in patients with breast cancer and that IL-17B expression upregulation is specifically associated with poorer survival in patients with basal-like breast cancer. We t...

Mesenchymal stem cells are important cells in tumor microenvironment. We have previously demonstrated that IL-17B/IL-17RB signal promoted progression of gastric cancer. In this study, we further explored the effect of IL-17B on mesenchymal stem cells in tumor microenvironment and its impact on the tumor progression. The results showed that IL-17B induced the expression of stemness-related genes...

17b-Hydroxysteroid dehydrogenase type 4 (17b-HSD4) is the most unusual among human 17b-HSDs. It is characterized by a multidomain structure, in which the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17b-HSD4 not only inactivates estradiol by conversion to estrone but its three protein domains also participate in successive steps of peroxisomal b-oxidation of longand...

Interleukin-17B (IL-17B) is a member of interleukin-17 family that displays a variety of proinflammatory and immune modulatory activities. In this study, we found that IL-17B mRNA was maximally expressed in the limb buds of 14.5 days post coitus (dpc) mouse embryo and declined to low level at 19.5 dpc. By immunohistochemical staining, the strongest IL-17B signals were observed in the cells of t...

The bis -sulfamoylated derivative of 2-methoxyestradiol (2-MeOE2), 2-methoxyestradiol-3,17-O,O-bis-sulfamate (2MeOE2bisMATE), has shown potent antiproliferative and antiangiogenic activity in vitro and inhibits tumor growth in vivo . 2-MeOE2bisMATE is bioavailable, in contrast to 2-MeOE2 that has poor bioavailability. In this study, we have examined the role of 17B-hydroxysteroid dehydrogenase ...

In smooth muscle cells (SMCs) isolated from rabbit carotid, femoral, and saphenous arteries, relative myosin isoform mRNA levels were measured in RT-PCR to test for correlations between myosin isoform expression and unloaded shortening velocity. Unloaded shortening velocity and percent smooth muscle myosin heavy chain 2 (SM2) and myosin light chain 17b (MLC(17b)) mRNA levels were not significan...

Do Nascimento, Carlos Antonio, Katalin Kauser, and Gabor M. Rubanyi. Effect of 17b-estradiol in hypercholesterolemic rabbits with severe endothelial dysfunction. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1788–H1794, 1999.— 17b-Estradiol prevents early vascular lesion development and may also affect advanced atherosclerosis. To test the antiatherosclerotic effect of estrogen under conditio...

We hypothesize that the endogenously present lipoidal estrogen fatty acid esters may have a stronger mitogenic action in the fat-rich mammary tissues than in the uterus. To test this hypothesis, we compared the activity of estradiol-17b-stearate (E2-17b-S) with that of estradiol-17b (E2) in stimulating the growth of mammary glandular cells versus the growth of uterine endometrial cells in ovari...

A, androstenedione Arom, aromatase AMH, anti Müllerian hormone cAMP, adenosine 3': 5'cyclic monophosphate DHT, dihydrotestosterone E, estrogen E1, estrone E2, estradiol 17B ER, estrogen receptor FT, female-producing temperature 3B-HSD, 3B-hydroxysteroid dehydrogenase-5-ene-4-ene isomerase 17B-HSD, 17B-hydroxysteroid dehydrogenase hsp, heat-shock protein MT, male-producing temperature P 450 arom...

Aim In this study, we determined the gene expression analysis of IL-17 gene family for early detection of subclinical inflammation among IBD patients. Background Cytokines have a vital role in the pathogenesis of inflammatory bowel disease (IBD). Interleukin-17 is the signature cytokine of the recently identified T helper 17 (Th17) cell subset. IL-17F is mainly involved in mucosal host defens...