Background: Dendritic cells (DC) are a key regulator of the immune response, and interferon- beta (IFN-β) is considered an immunomodulatory molecule for DC. Objective: The purpose of this study was to evaluate the ability of IFN-β treated DC to induce cytokine secretion by CD4+ T cells. Methods: Dendritic cells were generated from blood monocytes with granulocyte-monocyte colony-stimulating fac...

The aim of this study was to investigate the immunomodulatory effects of Spirulina platensis (S.platensis) by measuring the levels of serum interleukin (IL)-4, IL-10, IL-17, tumor necrosis factor(TNF)-α and interferon (IFN)-|γ| in mice suffered from systemic candidiasis and breast cancer. Theaqueous extract of S. platensis was selected for this study. Balb/C female mice were inoculated withCand...

Background: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor interaction. Objective: To investigate the percentages of CD8+ lymphocytes and their subsets in...

The contribution of the proinflammatory cytokines IFN-gamma and IL-17 to the pathogenesis of experimental arthritis is controversial. In proteoglycan (PG)-induced arthritis (PGIA), severe arthritis is dependent on the production of IFN-gamma, whereas IL-17 is dispensable. In collagen-induced arthritis and Ag-induced arthritis, although high levels of IFN-gamma are secreted, disease is exacerbat...

background: dendritic cells (dc) are a key regulator of the immune response, and interferon- beta (ifn-β) is considered an immunomodulatory molecule for dc. objective: the purpose of this study was to evaluate the ability of ifn-β treated dc to induce cytokine secretion by cd4+ t cells. methods: dendritic cells were generated from blood monocytes with granulocyte-monocyte colony-stimulating fac...

conclusions moderate exercise for 8 weeks increased the ifn-γ and decreased the il-17 serum levels in the morphine-dependent rats. for this reason, this type of exercise can improve the function of the immune system during morphine withdrawal syndrome. results after 8 weeks of exercise, a significant increase was observed in the serum ifn-γ level in the ht group (251.17 ± 13.045) in comparison ...

Background & Objective: Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic inflammatory immune response. Current therapies mostly rely on glucocorticoids which are accompanied by side-effects and mostly fail to achieve a favorable remission. Th17 subpopulation of T cells is increased in exacerbated SLE as IL-17 cytokine is overexpressed. ...

Objective(s): Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are regarded as autoimmune diseases of the central nervous system (CNS).  The CNS, testes, and eyes are immune privileged sites.  It was initially presumed that ocular involvement in EAE and infertility in MS are neural-mediated.  However, inflammatory molecules...

Th17 cells have been named after their signature cytokine IL-17 and accumulating evidence indicates their involvement in the induction and progression of inflammatory diseases. In addition to IL-17 single-producing T cells, IL-17/IFN-gamma double-positive T cells are found in significantly elevated numbers in inflamed tissues or blood from patients with chronic inflammatory disorders. Because I...