BR-16A is an herbal (non-allopathic) medication used in India to enhance cognition. Sixty adult male Sprague Dawley rats received either BR-16A (200 mg/kg/day) or vehicle alone for 16 days. During the first 7 days, the rats were trained in a spatial memory task using the Hebb Williams complex maze. Once a day for the next 2 days, rats in BR-16A and control groups received either true or sham el...

Treatment of laboratory mice and rats with the adrenal steroid, dehydroepiandrosterone (DHEA), produces antiobesity and broad spectrum tumor chemopreventive activity. Certain side effects are associated with DHEA administration which could limit its usefulness as a drug. DHEA can be metabolized into both testosterone and estrone and also increases liver weight and liver catalase activity. We ha...

BR-16A (Mentat 50-500 mg/kg) improved acquisition and retention of a passive avoidance task in a step-down paradigm in mice. BR-16A (50-500 mg/kg) reversed scopolamine (0.3 mg/kg)-induced disruption of acquisition and retention. BR 16-A (50 and 100 mg/kg) attenuated amnesia produced by the acute treatment with electroconvulsive shock (ECS), immediately after training. Chronic treatment with ECS...

In the present study, two new series of pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety were designed, synthesised, and evaluated for their cytotoxic activity. The benzamide derivatives 16a–e showed higher cytotoxicity than corresponding Schiff bases 15a–e. Compounds 16a,b,d also inhibited growth MCF-7/ADR cells with IC50 in range 0.52–6.26 ?M. Interestingly, compounds less against normal MR...

Flavanoids bearing a 1,4-benzodioxane moiety [rac-15a, -16a, -17, -18, (-)-15a, (-)-16a] were prepared from protocatechualdehyde (5) and tested for inhibitory activity on the superoxide anion (O2.-) release by human polymorphonuclear leukocytes (PMNLs).

BR-16A is a herbal (non-allopathic) medication used in India to enhance cognition in this study. Wistar rats (n=24) received either BR-16A (200 mg/kg/day) or vehicle alone for 3 weeks. Over 4 consecutive days during the third week, the rats were tested for learning in the Hebb Williams complex maze. BR-16A treated rats showed significant learning while controls did not. It is concluded that BR-...

BR-16A is an herbal (non allopathic) medication used in India to enhance cognition. In experiment 1, 28 Wistar rats received either BR-16A (200 mg/kg/day) or vehicle alone for 3 weeks. During the third week, the rats were tested for learning in the Hebb Williams complex maze. BR-16A-treated rats showed significantly better learning than did controls. Experiment 2 was conducted identically excep...

The effectiveness of BR-16A, a herbal psychotropic preparation, was investigated in shortterm memory paradigms in mice. The passive avoidance task consisted of an electric grid with a centrally located shock-free zone (SFZ). BR-16A (50-500 mg/kg) improved passive avoidance acquisition as well as retrieval in mice. BR-16A reversed scopolamine (0.3 mg/kg)-induced disruption of learning and memory...

The antistress effects of BR-16A, a polyherbal preparation and its interaction with GABAergic modulators against social isolation-induced stress were investigated in the present study. Isolation stress was induced by keeping the mice (Laca strain) individually in each cage for 3 weeks and various drug treatments were given for a period of 5 days before the start of the experiments. The various ...