Visualization of infection and the associated host response has been challenging in adult vertebrates. Owing to their transparency, zebrafish larvae have been used to directly observe infection in vivo; however, such larvae have not yet developed a functional adaptive immune system. Cells involved in adaptive immunity mature later and have therefore been difficult to access optically in intact ...

Page Preamble ..................................................................1642 Introduction.............................................................1643 Aortic wall disease...................................................1643 Inherited disease ..................................................1643 Aortic disease in infancy and childhood .............1645 Ageing of the aorta............

The expression and functional role of ether-à-go-go-related gene (erg) K+ channels were examined in the bovine epididymal duct. Sperm transit through the epididymal duct relies on spontaneous phasic contractions (SC) of the peritubular smooth muscle wall. Isometric tension studies revealed SC-enhancing effects of the erg channel blockers E-4031, dofetilide, cisapride, and haloperidol and SC-sup...

NS1643 is one of the small molecule HERG (Kv11.1) channel activators and has also been found to increase erg2 (Kv11.2) currents. We now investigated whether NS1643 is also able to act as an activator of Kv11.3 (erg3) channels expressed in CHO cells. Activation of rat Kv11.3 current occurred in a dose-dependent manner and maximal current increasing effects were obtained with 10 µM NS1643. At thi...

Hole U1309A: Latitude: 30° 10.1081' N, Longitude: 42° 07.1101' W, 1643 mbsl Hole U1309B: Latitude: 30° 10.1081' N, Longitude: 42° 07.1101' W, 1643 mbsl Hole U1309C: Latitude: 30° 10.1081' N, Longitude: 42° 07.1209' W, 1638 mbsl Hole U1309D: Latitude: 30° 10.1195' N, Longitude: 42° 07.1131' W, 1645 mbsl Hole U1309E: Latitude: 30° 10.1207' N, Longitude: 42° 07.1057' W, 1644 mbsl Hole U1309F: Lati...

Objective. The present study was performed to investigate the effects and mechanisms of miR-99a on LPS-induced endothelial cell inflammation, as well as the regulation of NF-κB on miR-99a production. Methods and Results. ELISA showed that LPS treatment significantly promoted the secretion of inflammatory factors (TNF-α, IL-6, IL-1β, and MCP-1). LPS treatment also inhibited miR-99a production an...