In the developing cochlea, sensory hair cell differentiation depends on the regulated expression of the bHLH transcription factor Atoh1. In mammals, if hair cells die they do not regenerate, leading to permanent deafness. By contrast, in non-mammalian vertebrates robust regeneration occurs through upregulation of Atoh1 in the surviving supporting cells that surround hair cells, leading to funct...

Clopidogrel, a thienopyridine antiplatelet prodrug, is metabolized by oxidation to 2-oxo-clopidogrel, followed by conversion to its pharmacologically active thiol metabolite. After oral administration of clopidogrel to humans, two thiol isomers (H3 andH4) are observed in plasma,with similar concentrations, and only H4 is active in humans. In this work, themechanism of stereoselectivity in the f...

The aryl hydrocarbon receptor (AHR) is a basic helix-loop-helix Per-Arnt-Sim transcription factor that mediates induction of metabolic enzymes and toxicity of certain environmental pollutants. Although AHR knockout (KO) mice develop cardiac hypertrophy, conflicting reports associate this pathology with hypotension or endothelin (ET)-1-dependent hypertension. Because hypertension occurred at mod...

*Dept. of Medicine, TN Medical College & BYL Nair Ch. Hospital, Mumbai 400 008. L was a Dutch storekeeper and part-time janitor in Delft. he was little educated, but his business and his job kept him comfortably off and he lived only for his hobby, grinding of lenses. He made lens after lens and was determined to make as perfect a lens as possible. These lenses were small, scarcely about 3-4 mm...

economic answer to any of the French or English studies of death from the standpoint of social history. It is a study of infant mortality as an indicator of the patterns that can be perceived if the statistics generated during the late nineteenth century are examined in the light of their social grouping. Now Spree does this very well. He is interested in the individual as an economic entity an...

2. Classification of Serotonin Receptors 1625 2.1. Gq/11-Coupled Receptor Types 1626 2.1.1. The 5-HT2A Receptor 1626 2.1.2. The 5-HT2B Receptor 1627 2.1.3. The 5-HT2C Receptor 1628 2.2. Gs-Coupled Receptor Types 1628 2.2.1. The 5-HT4 Receptor 1629 2.2.2. The 5-HT6 Receptor 1629 2.2.3. The 5-HT7 Receptor 1629 2.3. Gi/o-Coupled Receptor Types 1630 2.3.1. The 5-HT1A Receptor 1630 2.3.2. The 5-HT1B...

Multinational companies and national governments pay considerable attention to labor cost and labor productivity differentials across countries. This paper analyzes total and unit labor differentials for a group of European and non-European countries in the 1960-1998 period. It deals with (i) the magnitude of total labor cost differences (ii) the developments in unit labor cost and labor produc...